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Invitrogen
KIF3A Recombinant Rabbit Monoclonal Antibody (1C8K4)
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Product Details
MA5-42885
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
1C8K4
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 600-699 of human KIF3A (Q9Y496).
Conjugate
Form
Liquid
Concentration
1.15 mg/mL
Amount
115 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: SH-SY5Y, Rat testis.
Immunogen sequence: YQEMIENYVH WNEDIGEWQL KCVAYTGNNM RKQTPVPDKK EKDPFEVDLS HVYLAYTEES LRQSLMKLER PRTSKGKARP KTGRRKRSAK PETVIDSLLQ
Target Information
The kinesins constitute a large family of microtubule-dependent motor proteins which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in cell division, intracellular transport and membrane trafficking events including endocytosis and transcytosis. Members of the heterotrimeric kinesin II family of microtubule associated motors generally contain two different motor subunits from the KIF3 family, which includes KIF3A, B and C. KIF3 isoforms mediate anterograde transport of membrane bound organelles in neurons and melanosomes, transport between the endoplasmic reticulum and the Golgi, and transport of protein complexes within cilia and flagella required for their morphogenesis. KIF3A may influence neurogenesis at the level of embryonic cellular events, where the asymmetry of the genetic control circuit controlling left-right (L-R) axis determination is defined. Loss of KIF3A function in mice photoreceptors causes apoptotic cell death, suggesting that kinesin II mediated transport is required for proper cell fate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: kinesin family protein 3A; kinesin-II subunit; Kinesin-like protein KIF3A; Microtubule plus end-directed kinesin motor 3A; microtubule-based motor; N-4 kinesin; unnamed protein product
Gene Aliases: FLA10; KIF3; KIF3A; Kifl; KLP-20; Kns3
UniProt ID: (Human) Q9Y496, (Mouse) P28741
Entrez Gene ID: (Human) 11127, (Mouse) 16568, (Rat) 84392
nucleotide binding
microtubule motor activity
protein binding
ATP binding
microtubule binding
cytoskeletal protein binding
ATP-dependent microtubule motor activity, plus-end-directed
ATPase activity
protein phosphatase binding
spectrin binding
small GTPase binding
macromolecular complex binding
protein complex binding
microtubule binding motor protein
organelle organization
microtubule-based movement
anterograde axonal transport
centriole-centriole cohesion
transport along microtubule
protein transport
cell projection organization
microtubule anchoring at centrosome
cilium morphogenesis
plus-end-directed vesicle transport along microtubule
protein localization to cell junction
in utero embryonic development
kidney development
heart looping
smoothened signaling pathway
determination of left/right symmetry
heart development
epidermis development
anterior/posterior pattern specification
dorsal/ventral pattern formation
dentate gyrus development
dorsal/ventral neural tube patterning
neural tube development
nonmotile primary cilium assembly
epidermal stem cell homeostasis
cilium assembly
positive regulation of receptor-mediated endocytosis
positive regulation of epithelial cell proliferation
inner ear receptor stereocilium organization
neural precursor cell proliferation
motile primary cilium assembly
metabolic process
neurogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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