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Invitrogen

HLA-ABCE Monoclonal Antibody (TP25.99SF)

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HLA-ABCE Monoclonal Antibody (TP25.99SF)

Product Details

MA5-44040

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
-

Immunohistochemistry (Frozen) (IHC (F))

Assay-dependent
-

Flow Cytometry (Flow)

1-4 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

TP25.99SF

Immunogen

IFN-gamma-treated human melanoma cells Colo 38
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

15mM sodium azide

Storage conditions

4°C, do not freeze

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2912972

Product Specific Information

This antibody recognizes an extracellular epitope on HLA-ABC and HLA-E molecules, but not HLA-G. It can be used for discrimination between HLA-G and other HLA-class I antigens.

Western blotting: non-reducing conditions.

Target Information

HLA-A, -B, and -C are major histocompatibility complex (MHC)-class I antigens. Like other class I molecules (i.e. HLA-E, -F, -G), HLA-A, -B, and -C are heterodimers consisting of a 40 - 45 kDa transmembrane glycoproteic alpha-chain, noncovalently combined to the invariant B2-microglobulin.

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: allele B-3515; B*3509; cell surface glycoprotein; integral membrane protein; exons 2-8; glycosylation aa 86, alpha domain 1 aa 1-24, alpha domain 2 aa 25-114, alpha domain 3 aa 207-298; glycosylation aa 86, alpha domain 1 aa 25-114, alpha domain 2 aa 115-206, alpha domain 3 aa 207-298; heavy chain; hla antigen; HLA B-1519; HLA class I antigen HLA-B; HLA class I histocompatibility antigen, A-1 alpha chain; HLA class I histocompatibility antigen, B alpha chain; HLA protein allele A25; HLA protein allele B37; HLA protein allele B51; HLA protein allele B57; HLA protein allele B7; HLA-A; HLA-A 2402; HLA-A*0201 alpha chain; human leukocyte antigen; HLA-A*0204; HLA-A*0207 alpha chain; human leukocyte antigen; HLA-A-0102 allele; HLA-A24AK; HLA-A25; HLA-B; HLA-B*4002; HLA-B-07ZEL allele; HLA-B-1501; HLA-B-1516; HLA-B-1520 allele; HLA-B-15AOH allele; HLA-B-15ZEL allele; HLA-B-27KSH allele; HLA-B-67LAV allele; This submission reports an HLA-B-6701 variant (HLA-B-67LAV) that differs from the published B-6701 sequence, GenBank Accession Number L17005; HLA-B18; HLA-B27 peptide; HLA-B39; HLA-B41 variant; HLA-B61; HLA-Bw-39-DBU allele; HLA-C antigen; HLA-Cw; HLA-Cw1 protein; HLA-Cw2 protein; HLA-Cw3 protein; HLA-E class I protein precursor; human leukocyte antigen; human leukocyte antigen-C alpha chain; leukocyte antigen class I-A; leukocyte antigen class I-B; lymphocyte antigen; major histocompatibility antigen HLA-C; major histocompatibility complex class I A; major histocompatibility HLA-Cw2.2 heavy chain; MHC class 1 antigen; MHC class I antigen E; MHC class I antigen heavy chain HLA-C; MHC class I antigen HLA-A heavy chain; MHC class I antigen HLA-B alpha chain; MHC class I antigen HLA-B heavy chain; MHC class I antigen SHCHA; MHC class I molecule; MHC class I-like alpha chain membrane-bound type; MHC class Ib antigen; MHC HLA-A cell surface antigen; MHC HLA-A10-alpha-2 chain precursor; MHC HLA-A2.4a chain; MHC HLA-A24 cell surface glycoprotein; MHC HLA-B cell surface glycoprotein; MHC HLA-B transmembrane glycoprotein; MHC HLA-B44; MHC HLA-B7 heavy chain precursor; MHC HLA-Bw46; MHC HLA-C-alpha-2 chain precursor; non-classical MHC class I antigen; nonclassical MHC class I antigen; similar to Homo sapiens MHC HLA-B39 mRNA with GenBank Accession Number L42024.1; subtype B*3508 differs at residue 156 (Leu->Arg) with subtype B*3501; unnamed protein product

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Gene Aliases: AS; B-4901; D6S204; HLA-6.2; HLA-JY3; HLAA; HLAB; HLAC; HLC-C; MHC; PSORS1; QA1

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UniProt ID: (Human) P04439, (Human) P01889, (Human) P10321, (Human) P13747

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Entrez Gene ID: (Human) 3105, (Human) 3106, (Human) 3107, (Human) 3133

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Function(s)
RNA binding receptor binding protein binding beta-2-microglobulin binding peptide antigen binding T cell receptor binding CD8 receptor binding TAP binding TAP complex binding chaperone binding receptor agonist activity MHC class I protein binding natural killer cell lectin-like receptor binding
Process(es)
T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity T cell mediated cytotoxicity directed against tumor cell target antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of exogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent peptide antigen assembly with MHC class I protein complex regulation of natural killer cell mediated immunity positive regulation of T cell cytokine production immune response detection of bacterium antibacterial humoral response antigen processing and presentation antigen processing and presentation of endogenous peptide antigen via MHC class I positive regulation of interferon-gamma production CD8-positive, alpha-beta T cell activation protection from natural killer cell mediated cytotoxicity antigen processing and presentation of exogenous peptide antigen via MHC class I defense response to Gram-positive bacterium T cell receptor signaling pathway positive regulation of CD8-positive, alpha-beta T cell proliferation positive regulation of memory T cell activation positive regulation of CD8-positive, alpha-beta T cell activation positive regulation of antibody-dependent cellular cytotoxicity adaptive immune response natural killer cell tolerance induction positive regulation of immunoglobulin production positive regulation of natural killer cell mediated immunity positive regulation of natural killer cell cytokine production signal transduction positive regulation of interleukin-13 production positive regulation of interleukin-4 production positive regulation of TRAIL production positive regulation of tumor necrosis factor production negative regulation of natural killer cell activation positive regulation of natural killer cell activation positive regulation of natural killer cell proliferation negative regulation of T cell proliferation negative regulation of natural killer cell mediated cytotoxicity positive regulation of natural killer cell mediated cytotoxicity regulation of T cell anergy defense response regulation of interleukin-12 production regulation of interleukin-6 production regulation of dendritic cell differentiation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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