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Invitrogen
RSK2 Recombinant Rabbit Monoclonal Antibody (JE63-19)
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FIGURE: 1 / 8
RSK2 Antibody (MA5-44775) in IHC (P)
Immunohistochemistry analysis of RSK2 in paraffin-embedded human breast carcinoma tissue. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 2 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with RSK2 Monoclonal antibody (Product # MA5-44775) using a dilution of 1:200 for 1 hour ... View More
Product Details
MA5-44775
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JE63-19
Immunogen
Synthetic peptide within human RSK2 aa 661-710/740.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 0.05% BSA, 40% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
RPS6KA3 (RSK2) is a serine/threonine kinase that modulates many cellular processes including transcription, adhesion, growth, survival, and proliferation. RPS6KA3 contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in the gene have been associated with Coffin-Lowry syndrome (CLS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 90 kDa ribosomal protein S6 kinase 3; epididymis secretory sperm binding protein; Insulin-stimulated protein kinase 1; ISPK-1; MAP kinase-activated protein kinase 1b; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; p90-RSK 3; pp90RSK2; ribosomal protein S6 kinase 2; Ribosomal protein S6 kinase alpha-3; ribosomal protein S6 kinase, 90kDa, polypeptide 3; Ribosomal S6 kinase 2; RPS6KA3; RSK-2; S6K-alpha-3; unnamed protein product
Gene Aliases: C130006E23; CLS; HU-3; ISPK-1; ISPK1; MAPKAPK-1b; MAPKAPK1B; MPK-9; MRX19; p90-RSK2; p90RSK3; pp90RSK2; RGD1563860; Rps6ka-rs1; RPS6KA3; RSK; RSK2; S6K-alpha3; XLID19
UniProt ID: (Human) P51812, (Mouse) P18654
Entrez Gene ID: (Human) 6197, (Mouse) 110651, (Rat) 501560
nucleotide binding
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
ribosomal protein S6 kinase activity
protein binding
ATP binding
kinase activity
transferase activity
protein kinase binding
metal ion binding
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
molecular_function
protein modifying enzyme
skeletal system development
toll-like receptor signaling pathway
signal transduction
chemical synaptic transmission
central nervous system development
positive regulation of cell growth
response to lipopolysaccharide
intracellular signal transduction
TORC1 signaling
negative regulation of apoptotic process
regulation of translation in response to stress
positive regulation of cell differentiation
positive regulation of transcription from RNA polymerase II promoter
regulation of translation
protein phosphorylation
cell cycle
phosphorylation
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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