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Invitrogen

HSP70/HSC70 Monoclonal Antibody (BB70), PerCP

View all (8) HSP70/HSC70 antibodies

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Product Details

MA5-45101

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:2,000
-

Immunocytochemistry (ICC/IF)

1:200
-

Immunoprecipitation (IP)

Assay-dependent
-
Product Specifications

Species Reactivity

Bovine, Dog, Chicken, Fruit fly, Fish, Guinea pig, Hamster, Human, Mammal, Mouse, Sheep, Pig, Rabbit, Rat, Xenopus, Yeast

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

BB70

Immunogen

Chicken HSP70/HSP90 complex

Conjugate

PerCP PerCP PerCP

Excitation/Emission Max

482/675 nm View spectra spectra

Form

Liquid

Concentration

1 mg/mL

Amount

200 µg

Purification

Protein G

Storage buffer

95.64mM phosphate/2.48mM MES, pH 7.2, with 0.5M EDTA

Contains

no preservative

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2931555

Product Specific Information

1 µg/mL of MA5-45101 was sufficient for detection of HSP70 and HSC70 in 20 µg of heat shocked HeLa cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 72 (HSP) and approximately 73kDa (HSC).

Target Information

HSPA4 (Heat Shock Protein Family A (Hsp70) Member 4) is a Protein Coding gene. Diseases associated with HSPA4 include Chagas Disease and Babesiosis. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Cellular responses to stimuli. An important paralog of this gene is HSPH1. HSPA8 (Heat Shock Protein Family A (Hsp70) Member 8) is a Protein Coding gene. Diseases associated with HSPA8 include Auditory System Disease and Borna Disease. Among its related pathways are Processing of Capped Intron-Containing Pre-mRNA and Selective autophagy. Gene Ontology (GO) annotations related to this gene include RNA binding and ubiquitin protein ligase binding. An important paralog of this gene is HSPA2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 70 kDa heat-shock-like protein; constitutive heat shock protein 70; epididymis luminal protein 33; epididymis secretory sperm binding protein Li 5a; epididymis secretory sperm binding protein Li 72p; Heat shock 70 kDa protein 4; Heat shock 70 kDa protein 8; heat shock 70-related protein APG-2; heat shock 70kd protein 10; heat shock 70kd protein 10 (HSC71); heat shock 70kD protein 4; heat shock 70kD protein 8; heat shock 70kDa protein 1-like; heat shock 70kDa protein 4; heat shock 70kDa protein 8; heat shock cognate 70; heat shock cognate 71 kD protein; heat shock cognate hsc73; heat shock cognate protein 54; Heat shock cognate protein 70; heat shock protein 4; heat shock protein 70 cognate; heat shock protein 8; heat shock protein A8; heat shock protein Apg-2; heat shock protein cognate 70; heat shock protein family A member 4; heat shock protein family A member 8; heat shock protein family H member 2; heat shock protein, 110 kDa; Hsc70 ATPase; hsp70 RY; HSPA4/HSPA8; IRP94; ischemia responsive 94 kDa protein; lipopolysaccharide-associated protein 1; LPS-associated protein 1; N-myristoyltransferase inhibitor protein 71; unnamed protein product

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Gene Aliases: 2410008N15Rik; 70kDa; APG-2; HEL-33; HEL-S-5a; HEL-S-72p; HS24/P52; HSC54; HSC70; hsc70.I; HSC71; Hsc73; Hsp110; HSP70; Hsp70RY; HSP71; HSP73; HSPA1; HSPA10; hspa1l; HSPH2; I79_004332; I79_022974; irp94; LAP-1; LAP1; mKIAA4025; NIP71; RY; XELAEV_18037286mg; xhsp70

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UniProt ID: (Dog) Q7YQC6, (Dog) Q2TFN9, (Human) P34932, (Human) P11142, (Chicken) O73885, (Bovine) P19120, (Rat) O88600, (Mouse) P63017, (Rat) P63018, (Chinese hamster) P19378

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Entrez Gene ID: (Dog) 403612, (Chicken) 416339, (Dog) 474680, (Sheep) 101122782, (Pig) 100524853, (Bovine) 536558, (Human) 3308, (Rabbit) 100338049, (Dog) 479406, (Sheep) 101112844, (Human) 3312, (Chicken) 395853, (Bovine) 281831, (Rabbit) 100348873, (Pig) 100511890, (Rat) 266759, (Mouse) 15525, (Guinea pig) 100735343, (Chinese hamster) 100764628, (Mouse) 15481, (Guinea pig) 100713849, (Rat) 24468, (Chinese hamster) 100689472, (Western clawed frog) 100037899, (Xenopus) 379760

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Function(s)
protein binding ATP binding adenyl-nucleotide exchange factor activity ATPase activity G-protein coupled receptor binding RNA binding enzyme binding MHC class II protein complex binding protein binding, bridging heat shock protein binding ubiquitin protein ligase binding protein binding involved in protein folding cadherin binding receptor agonist activity chaperone binding C3HC4-type RING finger domain binding ATP-dependent protein disaggregase activity ATP-dependent protein folding chaperone unfolded protein binding misfolded protein binding clathrin-uncoating ATPase activity macromolecular complex binding RNA polymerase II sequence-specific DNA binding transcription factor binding phosphatidylserine binding receptor binding lipid binding A1 adenosine receptor binding AP-3 adaptor complex binding peptide binding lncRNA binding prostaglandin binding
Process(es)
kidney development negative regulation of protein phosphorylation protein folding negative regulation of gene expression protein import into mitochondrial matrix negative regulation of apoptotic process positive regulation of angiogenesis chaperone-mediated protein complex assembly neuron apoptotic process regulation of microglial cell activation G1/S transition of mitotic cell cycle mRNA splicing, via spliceosome positive regulation of T cell mediated cytotoxicity protein import into nucleus autophagy signal transduction skeletal muscle tissue development axo-dendritic transport response to xenobiotic stimulus response to nickel cation positive regulation of gene expression negative regulation of cardiac muscle cell apoptotic process response to activity cerebellum development protein catabolic process positive regulation of cell migration forebrain development regulation of protein stability response to estradiol response to progesterone protein-containing complex disassembly cellular response to heat protein refolding response to starvation positive regulation of catalytic activity intracellular protein transmembrane import modulation by host of viral process positive regulation by host of viral genome replication estrous cycle response to ethanol positive regulation of proteolysis negative regulation of transcription, DNA-templated ATP metabolic process protein autophosphorylation positive regulation of mRNA splicing, via spliceosome positive regulation of phagocytosis regulation of cell cycle regulation of protein complex stability chaperone-mediated autophagy late endosomal microautophagy protein targeting to lysosome involved in chaperone-mediated autophagy cellular response to hydrogen peroxide cellular response to cadmium ion clathrin coat disassembly positive regulation of lysosomal membrane permeability maintenance of postsynaptic specialization structure regulation of postsynapse organization positive regulation of ferroptosis negative regulation of NLRP3 inflammasome complex assembly negative regulation of fibril organization positive regulation of protein refolding chaperone-mediated autophagy translocation complex disassembly slow axonal transport response to odorant response to stress response to unfolded protein cellular response to starvation negative regulation of signal transduction regulation of cytoplasmic pattern recognition receptor signaling pathway regulation of programmed cell death regulation of protein complex assembly negative regulation of cellular component organization membrane organization cellular response to steroid hormone stimulus regulation of fibril organization regulation of protein import gastrulation embryo development ending in birth or egg hatching vesicle-mediated transport cellular response to unfolded protein embryonic organ development chaperone mediated protein folding requiring cofactor chaperone-mediated protein transport involved in chaperone-mediated autophagy mRNA processing RNA splicing synaptic vesicle uncoating positive regulation of microtubule nucleation regulation of mitotic spindle assembly
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