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Invitrogen

HSP90 alpha Monoclonal Antibody (2G5.G3), APC

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HSP90 alpha Monoclonal Antibody (2G5.G3), APC

Product Details

MA5-45180

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000
-

Immunocytochemistry (ICC/IF)

1:100
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

2G5.G3

Immunogen

Recombinant Full Length Human HSP90alpha Protein
3D Epitope / Immunogen

Conjugate

APC APC APC

Excitation/Emission Max

651/660 nm View spectra spectra

Form

Liquid

Concentration

1 mg/mL

Amount

200 µg

Purification

Protein G

Storage buffer

95.46mM phosphate/2.48mM MES, pH 7.4, with 2mM EDTA

Contains

no preservative

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2931634

Product Specific Information

0.5 µg/mL of MA5-45180 was sufficient for detection of HSP90alpha in 20 µg of heat shocked HeLa cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 90kDa. HSP90 alpha -specific (>96% alpha -specific by ELISA)

Target Information

Heat shock proteins (HSP) are proteins that are expressed in response to various biological stress, including heat. HSP90 is a 90 kDa protein that is induced under stress conditions, but is also one of the most abundant cellular proteins found under non-stress conditions. HSP90 has been found to be associated with a number of other intracellular proteins, including steroid receptors, actin, tubulin, and some kinases. It has been suggested that HSP90 is necessary to maintain structural integrity of at least some steroid receptors to allow for ligand binding during receptor activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: epididymis luminal secretory protein 52; epididymis secretory sperm binding protein Li 65p; heat shock 86 kDa; heat shock 90kD protein 1, alpha; heat shock 90kD protein 1, alpha-like 4; heat shock 90kD protein, alpha-like 4; heat shock 90kDa protein 1, alpha; Heat shock protein; heat shock protein 1, alpha; heat shock protein 86; heat shock protein 90, alpha (cytosolic), class A member 1; heat shock protein 90kDa alpha (cytosolic), class A member 1; heat shock protein 90kDa alpha family class A member 1; heat shock protein family C member 1; heat shock protein, 1; heat shock protein, 86 kDa 1; heat shock protein, 89 kDa; Heat shock protein90; heat-shock protein hsp86; HSP; HSP 86; HSP 90 alpha; HSP86; lipopolysaccharide-associated protein 2; LPS-associated protein 2; renal carcinoma antigen NY-REN-38; TSTA; tumor-specific transplantation 86 kDa antigen; unnamed protein product

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Gene Aliases: 86kDa; 89kDa; EL52; HEL-S-65p; Hsp103; hsp4; HSP86; Hsp86-1; Hsp89; HSP89A; Hsp90; HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1; HSPCAL4; HSPN; LAP-2; LAP2

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UniProt ID: (Human) P07900, (Mouse) P07901, (Rat) P82995

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Entrez Gene ID: (Human) 3320, (Mouse) 15519, (Rat) 299331

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Function(s)
UTP binding CTP binding RNA binding mRNA binding protein binding ATP binding GTP binding ATPase activity sulfonylurea receptor binding protein phosphatase binding MHC class II protein complex binding nitric-oxide synthase regulator activity TPR domain binding ubiquitin protein ligase binding dATP binding AP-3 adaptor complex binding identical protein binding protein homodimerization activity histone deacetylase binding protein binding involved in protein folding ion channel binding tau protein binding GTPase binding Rho GDP-dissociation inhibitor binding DNA polymerase binding scaffold protein binding disordered domain specific binding ATP-dependent protein folding chaperone enzyme-substrate adaptor activity protein tyrosine kinase binding protein carrier chaperone
Process(es)
neuron migration response to dietary excess activation of innate immune response positive regulation of defense response to virus by host skeletal muscle contraction protein folding nitric oxide biosynthetic process response to unfolded protein response to heat response to cold response to xenobiotic stimulus response to salt stress positive regulation of lamellipodium assembly cardiac muscle cell apoptotic process negative regulation of striated muscle cell apoptotic process protein import into mitochondrial matrix regulation of protein ubiquitination positive regulation of protein polymerization response to follicle-stimulating hormone positive regulation of interferon-beta production regulation of protein localization cellular response to heat response to isolation stress cellular response to platelet-derived growth factor stimulus protein refolding response to cocaine positive regulation of protein import into nucleus regulation of apoptotic process response to estrogen positive regulation of nitric oxide biosynthetic process positive regulation of cytotoxic T cell differentiation positive regulation of protein catabolic process positive regulation of cell size response to antibiotic protein stabilization chaperone-mediated protein complex assembly protein maturation positive regulation of cardiac muscle contraction response to caloric restriction cellular response to hydrogen peroxide cellular response to lipopolysaccharide cellular response to mechanical stimulus cellular response to hypoxia cellular response to virus regulation of postsynaptic membrane neurotransmitter receptor levels neurofibrillary tangle assembly telomerase holoenzyme complex assembly telomere maintenance via telomerase regulation of protein complex stability chaperone-mediated autophagy mitochondrial transport positive regulation of telomere maintenance via telomerase regulation of protein complex assembly protein unfolding nitric oxide metabolic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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