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Invitrogen

SHANK3 Monoclonal Antibody (S69), APC

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SHANK3 Monoclonal Antibody (S69), APC

Product Details

MA5-45458

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100
-

Immunocytochemistry (ICC/IF)

1:100
-

Immunoprecipitation (IP)

Assay-dependent
-

Antibody Microarray (Ab Microarray)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

S69

Immunogen

Synthetic peptide amino acids 840-857 of rat Shank3
3D Epitope / Immunogen

Conjugate

APC APC APC

Excitation/Emission Max

651/660 nm View spectra spectra

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

95.46mM phosphate/2.48mM MES, pH 7.4, with 2mM EDTA

Contains

no preservative

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2931912

Product Specific Information

1 µg/mL of MA5-45458 was sufficient for detection of Shank3 in 10 µg COS cell lysate transiently transfected with Shank3 by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 190kDa. No cross-reactivity against Shank1 or Shank2.

Target Information

SHANK3 is a major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. It interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. SHANK3 plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, SHANK3 participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. It also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. SHANK3 may be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. (Uniprot)

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: proline rich synapse associated protein 2; Proline-rich synapse-associated protein 2; ProSAP2; SH3 and multiple ankyrin repeat domains protein 3; SH3 and multiple ankyrin repeat domains protein 3 variant c-3; SH3 and multiple ankyrin repeat domains protein 3 variant c-4; SH3 and multiple ankyrin repeat domains-like protein 3 variant 1; SH3 and multiple ankyrin repeat domains-like protein 3 variant 2; SH3 and multiple ankyrin repeat domains-like protein 3 variant 3; SH3 and multiple ankyrin repeat domains-like protein 3 variant c-1; SH3 and multiple ankyrin repeat domains-like protein 3 variant c-2; SH3 and multiple ankyrin repeat domains-like protein 3 variant d-1; SH3 and multiple ankyrin repeat domains-like protein 3 variant d-2; SH3 and multiple ankyrin repeat domains-like protein 3 variant d-3; SH3 and multiple ankyrin repeat domains-like protein 3 variant e-1; SH3 and multiple ankyrin repeat domains-like protein 3 variant e-2; SH3/ankyrin domain gene 3; shank postsynaptic density protein; Shank postsynaptic density protein 3a; Shank3; shank3 postsynaptic density protein; shank3 splice variant II; shank3 splice variant III; shank3 splice variant IV; shank3e splice variant III; shank3e splice variant IV; SPANK 2; SPANK-2; SPANK2

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Gene Aliases: AI841104; DEL22q13.3; KIAA1650; PROSAP2; PSAP2; SCZD15; SHANK3; Shank3b; SHANK3c-3; SHANK3c-4; SPANK-2

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UniProt ID: (Human) Q9BYB0, (Mouse) Q4ACU6, (Rat) Q9JLU4

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Entrez Gene ID: (Human) 85358, (Mouse) 58234, (Rat) 59312

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Function(s)
actin binding protein binding zinc ion binding SH3 domain binding GKAP/Homer scaffold activity ionotropic glutamate receptor binding scaffold protein binding protein C-terminus binding identical protein binding protein self-association
Process(es)
MAPK cascade embryonic epithelial tube formation synapse assembly learning memory striatal medium spiny neuron differentiation adult behavior negative regulation of actin filament bundle assembly social behavior locomotory exploration behavior vocal learning negative regulation of cell volume positive regulation of long-term neuronal synaptic plasticity brain morphogenesis neuromuscular process controlling balance protein oligomerization positive regulation of synapse structural plasticity positive regulation of synaptic transmission, glutamatergic dendritic spine morphogenesis positive regulation of dendritic spine development regulation of dendritic spine morphogenesis vocalization behavior postsynaptic density assembly AMPA glutamate receptor clustering NMDA glutamate receptor clustering guanylate kinase-associated protein clustering regulation of long-term synaptic potentiation positive regulation of long-term synaptic potentiation positive regulation of glutamate receptor signaling pathway regulation of long term synaptic depression positive regulation of excitatory postsynaptic potential regulation of grooming behavior regulation of behavioral fear response positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity associative learning synapse organization cognition
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