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NMDAR2B Monoclonal Antibody (S59), APC

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NMDAR2B Monoclonal Antibody (S59), APC

Product Details

MA5-45462

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100
-

Immunocytochemistry (ICC/IF)

1:100
-

Immunoprecipitation (IP)

Assay-dependent
-

Antibody Microarray (Ab Microarray)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

S59

Immunogen

Fusion protein amino acids 20-271 (extracellular N-terminus) of rat NR2B
3D Epitope / Immunogen

Conjugate

APC APC APC

Excitation/Emission Max

651/660 nm View spectra spectra

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

95.64mM phosphate/2.48mM MES, pH 7.4, with 0.5M EDTA

Contains

no preservative

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2931916

Product Specific Information

1 µg/mL of MA5-45462 was sufficient for detection of NR2B in 10 µg of rat brain lysate by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 166kDa. No cross-reactivity against NR2A.

Target Information

NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. NMDA receptors (NMDAR) have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDAR play a role in neuronal development and has been implicated in several disorders of the central nervous system including Alzheimer's Disease, epilepsy and ischemic neuronal cell death. Overexpression of the NR2B subunit of the receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression. Tyr1472 on NR2B is phosphorylated and this may lead to the increased expression of the NMDAR at the synapse that plays a role in synaptic plasticity. NMDR2B is a heterotrimer comprised of seven enetically encoded and differentially expressed subunits that include NR1, NR2 and NR3. Diseases associated with the dysfunction of NMDAR2B include epileptic encephalopathy, autosomal dominant 6-related mental retardation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: GluN2B(alt_5'UTR); glutamate [NMDA] receptor subunit epsilon-2; glutamate receptor; glutamate receptor subunit epsilon-2; glutamate receptor, ionotropic, N-methyl D-aspartate 2B; glutamate receptor, ionotropic, NMDA2B; GRIN 2B; HGNC:4586; hNR 3; MGC142178; MGC142180; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 3; NMDAR2B; NMDE2; NME2; NR2B; unnamed protein product

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Gene Aliases: DEE27; EIEE27; GluN2B; GluRepsilon2; hNR3; MRD6; NMDAR2B; NR2B; NR3

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UniProt ID: (Human) Q13224, (Rat) Q00960, (Mouse) Q01097

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Entrez Gene ID: (Human) 2904, (Rat) 24410, (Mouse) 14812

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Function(s)
beta-amyloid binding NMDA glutamate receptor activity ion channel activity protein binding zinc ion binding ligand-gated ion channel activity glycine binding glutamate binding glutamate-gated calcium ion channel activity signaling receptor activity ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential receptor binding interleukin-1 receptor binding extracellular-glutamate-gated ion channel activity cation channel activity calcium channel activity beta-catenin binding protein kinase binding D2 dopamine receptor binding glutamate receptor binding ionotropic glutamate receptor binding small molecule binding macromolecular complex binding cell adhesion molecule binding scaffold protein binding protein serine/threonine kinase binding heterocyclic compound binding protein tyrosine kinase binding ionotropic glutamate receptor activity
Process(es)
ion transport glutamate receptor signaling pathway chemical synaptic transmission brain development learning or memory calcium-mediated signaling ionotropic glutamate receptor signaling pathway synaptic transmission, glutamatergic regulation of membrane potential response to ethanol regulation of synaptic plasticity regulation of neuronal synaptic plasticity protein heterotetramerization positive regulation of synaptic transmission, glutamatergic excitatory postsynaptic potential long-term synaptic potentiation calcium ion transmembrane import into cytosol cation transmembrane transport excitatory chemical synaptic transmission regulation of presynaptic membrane potential negative regulation of dendritic spine maintenance regulation of cation transmembrane transport positive regulation of excitatory postsynaptic potential action potential behavioral fear response response to hypoxia in utero embryonic development startle response suckling behavior response to amphetamine cation transport calcium ion transport cellular calcium ion homeostasis sensory organ development learning memory long-term memory associative learning response to mechanical stimulus response to toxic substance response to carbohydrate response to manganese ion response to lead ion cellular response to magnesium starvation positive regulation of glutamate secretion response to amine trigeminal motor nucleus development hippocampus development cerebral cortex development auditory behavior regulation of ARF protein signal transduction response to magnesium ion multicellular organismal response to stress response to cytokine response to nicotine response to cocaine fear response receptor clustering regulation of MAPK cascade response to antibiotic sensitization regulation of long-term neuronal synaptic plasticity behavioral response to pain detection of mechanical stimulus involved in sensory perception of pain response to calcium ion response to methylmercury response to electrical stimulus response to other organism regulation of postsynaptic membrane potential response to growth hormone response to fungicide cellular response to amino acid stimulus cellular response to manganese ion cellular response to dsRNA cellular response to growth factor stimulus cellular response to corticosterone stimulus cellular response to lipid positive regulation of inhibitory postsynaptic potential regulation of cAMP/PKA signal transduction regulation of long term synaptic depression response to glycoside cellular response to forskolin cellular response to curcumin response to hydrogen sulfide rhythmic process positive regulation of synaptic transmission neuromuscular process
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