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Invitrogen
CACNG2/4/8 Monoclonal Antibody (N245/36), APC
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FIGURE: 1 / 3
CACNG2/4/8 Antibody (MA5-45584) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis using human neuroblastoma cells. Fixation involved 4% Formaldehyde for 15 min at RT. Samples were incubated with TARP Gamma2/4/8 (Stargazin) monoclonal antibody (Product # MA5-45584) at 1:100 for 60 min at RT, followed by Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain used was Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1... View More
Product Details
MA5-45584
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
N245/36
Immunogen
Fusion protein amino acids 203-323 (Cytoplasmic C-terminus) of rat TARPGamma2
Conjugate
Excitation/Emission Max
651/660 nm
View spectra
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
95.46mM phosphate/2.48mM MES, pH 7.4, with 2mM EDTA
Contains
no preservative
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
1 µg/mL of MA5-45584 was sufficient for detection of TARP Gamma2/4/8 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 35-55kDa. Does not cross-react with TARPGamma3.
This antibody was formerly sold as clone S245-36.
Target Information
Voltage-dependent calcium channel gamma-2 subunit, TARPGamma2 or Stargazin is encoded by the gene CACNG2 and is the transmembrane gamma subunit of the L-type calcium channel. Stargazin is in involved in regulation and trafficking of the ligand gated ion channel AMPA receptors. It is thought to play a role in learning and memory. Diseases associated with this gene include forms of deafness, Mental Retardation and childhood absnce epilepsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CACNG2; calcium channel, voltage-dependent, gamma subunit 4; calcium channel, voltage-dependent, gamma subunit 8; Neuronal voltage-gated calcium channel gamma-2 subunit; Neuronal voltage-gated calcium channel gamma-4 subunit; Neuronal voltage-gated calcium channel gamma-8 subunit; Stargazin; TARP gamma 2; TARP gamma 8; TARP gamma-2; TARP gamma-4; TARP gamma-8; Transmembrane AMPAR regulatory protein gamma-2; Transmembrane AMPAR regulatory protein gamma-4; Transmembrane AMPAR regulatory protein gamma-8; unnamed protein product; Voltage-dependent calcium channel gamma-2 subunit; Voltage-dependent calcium channel gamma-4 subunit; Voltage-dependent calcium channel gamma-8 subunit
Gene Aliases: AI413107; AW060990; AW491861; B230105C07Rik; B930041E13Rik; CACNG2; CACNG4; CACNG6; CACNG8; Ipr328; mir-935; MRD10; stargazer; stargazin; Stg; wag; waggler
UniProt ID: (Human) Q9Y698, (Human) Q9UBN1, (Human) Q8WXS5, (Rat) Q71RJ2, (Mouse) O88602, (Rat) Q8VHW9, (Mouse) Q9JJV4, (Rat) Q8VHW5
Entrez Gene ID: (Human) 10369, (Human) 27092, (Human) 59283, (Rat) 84347, (Mouse) 12300, (Rat) 140725, (Mouse) 54377, (Rat) 140729, (Mouse) 81905
protein targeting to membrane
ion transport
calcium ion transport
neuromuscular junction development
transmission of nerve impulse
ion transmembrane transport
regulation of membrane potential
neurological system process
response to calcium ion
membrane depolarization
positive regulation of synaptic transmission, glutamatergic
membrane hyperpolarization
eye blink reflex
calcium ion transmembrane transport
postsynaptic neurotransmitter receptor diffusion trapping
regulation of postsynaptic membrane neurotransmitter receptor levels
neurotransmitter receptor localization to postsynaptic specialization membrane
positive regulation of protein localization to basolateral plasma membrane
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
response to cocaine
regulation of ion transmembrane transport
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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