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Invitrogen

QKI Monoclonal Antibody (N147/6), APC

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QKI Monoclonal Antibody (N147/6), APC

Product Details

MA5-45689

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (IHC)

Assay-dependent
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

N147/6

Immunogen

Fusion protein amino acids 1-341 (full-length) of human QKI-5.
3D Epitope / Immunogen

Conjugate

APC APC APC

Excitation/Emission Max

651/660 nm View spectra spectra

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

95.64mM phosphate/2.48mM MES, pH 7.4, with 0.5M EDTA

Contains

no preservative

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2932143

Product Specific Information

Mouse: 100% identity (341/341 amino acids identical). Rat: 99% identity (339/341 amino acids identical) >90% identity with QKI-6, QKI-7 and QKI-7b.

1 µg/mL of MA5-45689 was sufficient for detection of Pan-QKI in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 36-38kDa.

This antibody was formerly sold as clone S147-6.

Target Information

This gene encodes the sacsin protein, which includes a UbL domain at the N-terminus, a DnaJ domain, and a HEPN domain at the C-terminus. The gene is highly expressed in the central nervous system, also found in skin, skeletal muscles and at low levels in the pancreas. This gene includes a very large exon spanning more than 12.8 kb. Mutations in this gene result in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), a neurodegenerative disorder characterized by early-onset cerebellar ataxia with spasticity and peripheral neuropathy. Sacsin has been found to protect against mutant ataxin-1. A pseudogene associated with this gene is located on chromosome 11. Alternative splicing of this gene results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DKFZp586I0923; homolog of mouse quaking QKI (KH domain RNA binding protein); lethal, Chr 17, U Wisconsin 1; protein quaking; protein quaking-like; QKI; QKI-5 protein; QKI-6 protein; QKI-7 protein; QKI-7b protein; QKI/LOC100132735 fusion; quaking; quaking homolog, KH domain RNA binding; quaking type II; quaking, KH domain containing RNA binding; QUAKING-3; RNA Binding (QKI); RNA binding protein HQK; rqkI; unnamed protein product

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Gene Aliases: 1110003F05Rik; 1500005P18; Hqk; hqkI; l(17)-1Wis; l17Wis1; QK; QK1; QK3

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UniProt ID: (Human) Q96PU8, (Mouse) Q9QYS9

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Entrez Gene ID: (Human) 9444, (Mouse) 19317, (Rat) 499022

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Function(s)
nucleic acid binding transcription coactivator activity RNA binding mRNA binding mRNA 3'-UTR binding protein binding miRNA binding internal N(7)-methylguanine-containing RNA reader activity
Process(es)
vasculogenesis mRNA processing spermatid development intracellular mRNA localization axon ensheathment positive regulation of gene expression negative regulation of cardiac muscle cell apoptotic process regulation of epithelial to mesenchymal transition positive regulation of neuron projection development microglia differentiation negative regulation of angiogenesis negative regulation of translation positive regulation of myelination negative regulation of type I interferon production stress granule assembly vascular smooth muscle cell differentiation myelination muscle cell differentiation long-chain fatty acid biosynthetic process positive regulation of cholesterol biosynthetic process regulation of macrophage differentiation negative regulation of macrophage differentiation positive regulation of transcription, DNA-templated regulation of mRNA splicing, via spliceosome mRNA stabilization regulation of astrocyte differentiation positive regulation of oligodendrocyte differentiation mRNA transport 3'-UTR-mediated mRNA destabilization negative regulation of cold-induced thermogenesis spliceosome-depend formation of circular RNA negative regulation of 3'-UTR-mediated mRNA stabilization positive regulation of 3'-UTR-mediated mRNA stabilization myofibroblast contraction negative regulation of miRNA catabolic process regulation of cell development regulation of multicellular organismal development
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