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THRA/THRB Monoclonal Antibody (H43), FITC

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THRA/THRB Monoclonal Antibody (H43), FITC

Product Details

MA5-45922

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
-

Immunohistochemistry (IHC)

1:100
-

Immunocytochemistry (ICC/IF)

1:250
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

H43

Immunogen

Synthetic peptide from the full length Human Thyroid hormone receptor protein
View immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

9.1mM sodium bicarbonate/PBS, pH 7.4, with 640.91mM DMSO, 136.36mM ethanolamine

Contains

no preservative

Storage conditions

4°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2932376

Product Specific Information

A 1:500 dilution of MA5-45922 was sufficient for detection of Pan-Thyroid hormone receptor in 10 µg of Hep G2 Human Hepatoblastoma Cell lysate by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Detects 70 kDa.

Target Information

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1; c-erb-A thyroid hormone receptor; c-erbA protooncogene; c-erbA-1; c-erbA-2; C-erbA-alpha; c-erbA-alpha2; c-erbA-beta; c-erbAalpha; c-erbAalpha2; EAR-7; ERBA-related 7; nuclear receptor; Nuclear receptor subfamily 1 group A member 1; Nuclear receptor subfamily 1 group A member 2; oncogene ERBA2; THR; THRA; Thyroid hormone receptor alpha; thyroid hormone receptor alpha 1; thyroid hormone receptor alpha 1 (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1 formerly ERBA1); Thyroid hormone receptor beta; thyroid hormone receptor beta 3; thyroid hormone receptor beta2delta; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian); thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2); thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian); TR; TR alpha 1; TR alpha 2; TR beta; TRbeta2Delta; triiodothyronine receptor; unnamed protein product; V-erbA-related protein 7

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Gene Aliases: 6430529J03Rik; AR7; AW259572; c-erbA; c-ERBA-1; C-ERBA-2; C-erba-alpha; C-ERBA-BETA; c-erbAbeta; CHNG6; EAR7; ERB-T-1; ERBA; ERBA1; ERBA2; GRTH; NR1A1; NR1A2; PRTH; RATT3REC; Rvr; T3R[a]; T3R[b]; T3Ralpha; T3Rbeta; T3rec; THR1; THRA; THRA1; THRA2; THRalpha; THRalpha1; THRalpha2; THRB; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2; TRalpha; TRalpha1; TRalpha2; TRb; TRbeta; TRbeta1

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UniProt ID: (Human) P10827, (Human) P10828, (Mouse) P63058, (Rat) P63059, (Mouse) P37242

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Entrez Gene ID: (Human) 7067, (Human) 7068, (Mouse) 21833, (Rat) 81812, (Mouse) 21834, (Rat) 24831

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding zinc ion binding TBP-class protein binding protein domain specific binding chromatin DNA binding sequence-specific DNA binding macromolecular complex binding metal ion binding thyroid hormone binding general transcription initiation factor binding transcription coactivator binding chromatin binding enzyme binding sequence-specific double-stranded DNA binding steroid receptor RNA activator RNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding steroid hormone receptor activity single-stranded RNA binding thyroid hormone receptor activity transcription factor binding protein complex binding protein homodimerization activity transcription regulatory region DNA binding intronic transcription regulatory region DNA binding protein heterodimerization activity protein dimerization activity double-stranded DNA binding C4 zinc finger nuclear receptor DNA-binding transcription factor zinc finger transcription factor gene-specific transcriptional regulator
Process(es)
negative regulation of transcription from RNA polymerase II promoter cartilage condensation ossification thyroid hormone mediated signaling pathway regulation of thyroid hormone mediated signaling pathway positive regulation of thyroid hormone receptor signaling pathway regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter learning or memory regulation of heart contraction female courtship behavior response to cold hormone-mediated signaling pathway organ morphogenesis negative regulation of RNA polymerase II transcriptional preinitiation complex assembly cell differentiation erythrocyte differentiation thyroid gland development regulation of myeloid cell apoptotic process mRNA transcription from RNA polymerase II promoter negative regulation of transcription, DNA-templated positive regulation of female receptivity positive regulation of transcription from RNA polymerase II promoter retinoic acid receptor signaling pathway regulation of lipid catabolic process Type I pneumocyte differentiation positive regulation of cold-induced thermogenesis negative regulation of DNA-templated transcription, initiation transcription, DNA-templated sensory perception of sound negative regulation of female receptivity retinal cone cell development cellular response to thyroid hormone stimulus retinal cone cell apoptotic process positive regulation of myotube differentiation intracellular receptor signaling pathway cytoplasmic sequestering of transcription factor steroid hormone mediated signaling pathway negative regulation of sequence-specific DNA binding transcription factor activity kidney development liver development brain development lung development adrenal gland development response to nutrient levels response to drug digestive tract development embryonic organ development positive regulation of cell proliferation regulation of lipid metabolic process positive regulation of chondrocyte differentiation positive regulation of ossification regulation of cholesterol metabolic process regulation of triglyceride metabolic process
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