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Invitrogen
c-Met Recombinant Rabbit Monoclonal Antibody (243), FITC
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Product Details
MA5-46681
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
243
Immunogen
Recombinant protein ecoding Human c-Met (Met1-Thr932).
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
100 µg/mL
Purification
Protein A
Storage buffer
PBS with 0.5% BSA
Contains
0.03% Proclin 300
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Human c-Met (Met1-Thr932) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Storage: This antibody can be stored at 2C-8C for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze!
Target Information
MET (cMET) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cMet; EC 2.7.10.1; Hepatocyte growth factor receptor; HGF receptor; HGF-SF receptor; HGF/SF receptor; met oncogene; MET proto-oncogene protein; oncogene MET; Proto-oncogene c-Met; sc MET; Scatter factor receptor; SF receptor; soluble c met; tyrosine kinase; hepatocyte growth factor receptor; HGFR; Tyrosine-protein kinase Met; unnamed protein product
Gene Aliases: AUTS9; c-Met; DA11; DFNB97; HGFR; MET; RCCP2
UniProt ID: (Human) P08581
Entrez Gene ID: (Human) 4233
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
hepatocyte growth factor-activated receptor activity
protein binding
ATP binding
kinase activity
transferase activity
semaphorin receptor activity
protein phosphatase binding
identical protein binding
molecular function activator activity
endothelial cell morphogenesis
liver development
signal transduction
cell surface receptor signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
regulation of gene expression
negative regulation of autophagy
neuron differentiation
pancreas development
positive regulation of microtubule polymerization
negative regulation of Rho protein signal transduction
positive regulation of transcription from RNA polymerase II promoter
hepatocyte growth factor receptor signaling pathway
cell development
animal organ development
branching morphogenesis of an epithelial tube
positive chemotaxis
negative regulation of stress fiber assembly
excitatory postsynaptic potential
establishment of skin barrier
negative regulation of thrombin receptor signaling pathway
semaphorin-plexin signaling pathway
negative regulation of hydrogen peroxide-mediated programmed cell death
negative regulation of guanyl-nucleotide exchange factor activity
positive regulation of endothelial cell chemotaxis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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