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Invitrogen
Ly-108 Recombinant Rabbit Monoclonal Antibody (002), APC
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FIGURE: 1 / 1
Ly-108 Antibody (MA5-46741) in Flow
Flow cytometry analysis of Ly-108 in human whole blood lymphocytes using Ly-108, APC Recombinant Monoclonal (Product # MA5-46741). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes.
Product Details
MA5-46741
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
002
Immunogen
Recombinant protein ecoding Human Ly-108 (Met1-Met226).
Conjugate
Excitation/Emission Max
651/660 nm
View spectra
Form
Liquid
Concentration
100 µg/mL
Purification
Protein A
Storage buffer
PBS with 0.5% BSA
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Human Ly-108 (Met1-Met226) and conjugated with APC under optimum conditions, the unreacted APC was removed.
Storage: This antibody can be stored at 2C-8C for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Target Information
Ly108, the mouse homologue of human SLAMF6 (signaling lymphocyte activation molecule family member 6), is expressed on NK cells, B cells, and T cells. Engagement of the Ly108 receptor enhances NK cell activity and increases the expression of IFN-gamma. This receptor plays a role in the inability of NK cells to kill Epstein Barr virus-infected B cells in X-linked lymphoproliferative disease. In Ly108 knock-out mice, CD4+ T cells show a diminished ability to produce IL-4 and exhibit defective neutrophil functions, indicating the importance of Ly108 in immune regulation and cellular function. Overall, Ly108 is crucial for modulating immune responses and maintaining effective immune cell activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Activating NK receptor; CD352; natural killer-, T- and B-cell antigen; NK-T-B-antigen; NTB-A; NTBA receptor; SLAM family member 6; unnamed protein product
Gene Aliases: CD352; KALI; KALIb; Ly108; NTB-A; NTBA; SF2000; SLAMF6; UNQ6123/PRO20080
UniProt ID: (Human) Q96DU3
Entrez Gene ID: (Human) 114836
adaptive immune response
immune system process
immune response
positive regulation of interferon-gamma production
positive regulation of interleukin-17 production
T cell activation
innate immune response
positive regulation of natural killer cell mediated cytotoxicity
T-helper 17 cell lineage commitment
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