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Invitrogen
GP130 Recombinant Rabbit Monoclonal Antibody (022), APC
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-46793
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
022
Immunogen
Recombinant protein encoding Mouse GP130 (Met1-Glu617).
Conjugate
APC
APC
APC
Excitation/Emission Max
651/660 nm
View spectra
Form
Liquid
Concentration
100 µg/mL
Purification
Protein A
Storage buffer
PBS with 0.5% BSA
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Mouse GP130 (Met1-Glu617) and conjugated with APC under optimum conditions, the unreacted APC was removed.
Storage: This antibody can be stored at 2C-8C for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Target Information
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GP130-RAPS; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; IL6R-beta; membrane glycoprotein 130; oncostatin-M receptor subunit alpha; unnamed protein product
Gene Aliases: 5133400A03Rik; CD130; D13Ertd699e; gp130
UniProt ID: (Mouse) Q00560
Entrez Gene ID: (Mouse) 16195
cytokine receptor activity
ciliary neurotrophic factor receptor activity
interleukin-6 receptor activity
interleukin-11 receptor activity
leukemia inhibitory factor receptor activity
oncostatin-M receptor activity
cytokine activity
ciliary neurotrophic factor receptor binding
interleukin-6 receptor binding
protein binding
coreceptor activity
growth factor binding
cytokine binding
interleukin-11 binding
interleukin-6 binding
protein tyrosine kinase activator activity
identical protein binding
interleukin-27 receptor activity
scaffold protein binding
columnar/cuboidal epithelial cell differentiation
positive regulation of adaptive immune response
glycogen metabolic process
triglyceride mobilization
signal transduction
JAK-STAT cascade
cell proliferation
positive regulation of cell proliferation
regulation of Notch signaling pathway
positive regulation of smooth muscle cell migration
cytokine-mediated signaling pathway
cell differentiation
response to cytokine
autocrine signaling
interleukin-11-mediated signaling pathway
oncostatin-M-mediated signaling pathway
positive regulation of T cell proliferation
negative regulation of neuron apoptotic process
positive regulation of osteoblast differentiation
positive regulation of Notch signaling pathway
positive regulation of astrocyte differentiation
leukemia inhibitory factor signaling pathway
negative regulation of cytosolic calcium ion concentration
intestinal epithelial cell development
interleukin-6-mediated signaling pathway
negative regulation of interleukin-6-mediated signaling pathway
interleukin-27-mediated signaling pathway
ciliary neurotrophic factor-mediated signaling pathway
receptor signaling pathway via STAT
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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