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Invitrogen
CEACAM1 Recombinant Rabbit Monoclonal Antibody (117), FITC
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FIGURE: 1 / 1
CEACAM1 Antibody (MA5-46839) in Flow
Flow cytometry analysis of CD66a (CEACAM1) in BABL/c mouse splenocytes using CEACAM1, FITC Recombinant Monoclonal (Product # MA5-46839). The histogram were derived from gated events with the forward and side light-scatter characteristics of viable spleen lymphocytes.
Product Details
MA5-46839
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
117
Immunogen
Recombinant protein encoding Mouse CEACAM1 (Met1-Gly428).
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
100 µg/mL
Purification
Protein A
Storage buffer
PBS with 0.5% BSA
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD66a (CEACAM1) (Met1-Gly428) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Storage: This antibody can be stored at 2C-8C for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Target Information
CEACAM1 is a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of only two has been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BGP-1; Biliary glycoprotein 1; Biliary glycoprotein D; carcinoembryonic antigen 1; carcinoembryonic antigen 7; Carcinoembryonic antigen-related cell adhesion molecule 1; CD66a; CEA cell adhesion molecule 1; CEA-related cell adhesion molecule 1; Cell adhesion molecule CEACAM1; hepatitis virus (MHV-4) susceptibility; hepatitis virus receptor; MHV-R; MHVR1; Murine hepatitis virus receptor
Gene Aliases: bb-1; Bgp; Bgp1; C-CAM; Cc1; CD66a; Cea-1; Cea-7; Cea1; Cea7; Ceacam1; Hv-2; Hv2; mCEA1; Mhv-1; MHVR; MHVR1; mmCGM1; mmCGM1a; mmCGM2
UniProt ID: (Mouse) P31809
Entrez Gene ID: (Mouse) 26365
negative regulation of cytokine production
homophilic cell adhesion via plasma membrane adhesion molecules
viral process
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
negative regulation of interleukin-2 production
positive regulation of T cell proliferation
negative regulation of T cell proliferation
positive regulation of MAP kinase activity
negative regulation by host of viral process
positive regulation by host of viral process
negative regulation by host of viral genome replication
negative regulation of JNK cascade
positive regulation of JNK cascade
viral entry into host cell
Peyer's patch development
positive regulation of immunoglobulin secretion
positive regulation of NFAT protein import into nucleus
positive regulation of activation-induced cell death of T cells
positive regulation of CD4-positive, alpha-beta T cell activation
positive regulation of CD4-positive, alpha-beta T cell proliferation
positive regulation of CD8-positive, alpha-beta T cell activation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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