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Invitrogen
PAI1 Recombinant Rabbit Monoclonal Antibody (004), HRP
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Product Details
MA5-52174
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
004
Immunogen
Recombinant Human PAI-1/SerpinE1 protein (1-402).
Conjugate
HRP
HRP
HRP
Form
Liquid
Concentration
100 µg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
PAI1 (plasminogen activator inhibitor 1) belongs to serine protease inhibitor superfamily, and is the principal inhibitor of tissue-type and urokinase-type plasminogen activators (tPA and uPA). Platelets are the main source of the circulating PAI11, but it is synthesized and secreted by many tissue and cell types, including fibroblasts, smooth muscle cells, endothelial cells, hepatocytes, and inflammatory cells. Expression of PAI11 can be regulated at the transcriptional level by many factors including growth factors, cytokines, hormones, inflammatory factors, glucose or lipid metabolites, vascular tone regulating factors, chemicals, and other environmental or physical factors. PAI1 is present at increased levels in various disease states, and has been linked to an increased occurrence of thrombosis in obesity, thrombophilia and the metabolic syndrome. Defects in PAI-1 are characterized by abnormal bleeding. PAI1 mediates inhibition of fibrinolysis by inhibiting the activity of plasminogen activator, and may promote neuronal survival. Other defects in PAI1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency). Alternatively spliced transcript variants encoding different isoforms of PAI1 have been found.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: endothelial plasminogen activator inhibitor; plas; plasminogen activator inhibitor-1; prebeta-migrating plasminogen activator inhibitor; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; serpin E1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; SERPINE-1; unnamed protein product
Gene Aliases: PAI; PAI-1; PAI1; PLANH1
UniProt ID: (Human) P05121
Entrez Gene ID: (Human) 5054
angiogenesis
response to bacterium
negative regulation of plasminogen activation
negative regulation of smooth muscle cell migration
positive regulation of blood coagulation
negative regulation of blood coagulation
negative regulation of cell migration
positive regulation of interleukin-8 production
negative regulation of cell adhesion mediated by integrin
positive regulation of leukotriene production involved in inflammatory response
fibrinolysis
positive regulation of angiogenesis
negative regulation of proteolysis
positive regulation of receptor-mediated endocytosis
positive regulation of inflammatory response
positive regulation of coagulation
defense response to Gram-negative bacterium
negative regulation of fibrinolysis
negative regulation of vascular wound healing
negative regulation of wound healing
negative regulation of thrombin receptor signaling pathway
cellular response to lipopolysaccharide
positive regulation of monocyte chemotaxis
replicative senescence
dentinogenesis
positive regulation of odontoblast differentiation
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of smooth muscle cell-matrix adhesion
negative regulation of endothelial cell apoptotic process
negative regulation of integrin-mediated signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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