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Invitrogen
CD86 Recombinant Rabbit Monoclonal Antibody (118), Biotin
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Product Details
MA5-52234
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
118
Immunogen
Recombinant Human CD86 protein (1-239).
Conjugate
Biotin
Biotin
Biotin
Form
Liquid
Concentration
0.63 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
CD86, along with CD80, is a member of the B7 family of costimulatory molecules and plays a crucial role in T cell activation and immune response regulation. CD86 is expressed at low levels on B cells, macrophages, and dendritic cells, and its expression is upregulated on B cells through various stimuli, including the BCR complex, CD40, and certain cytokine receptors. As a type I membrane protein and member of the immunoglobulin superfamily, CD86 serves as a ligand for the T cell surface proteins CD28 and CTLA-4 (CD152). The interaction between CD86 and CD28 provides a costimulatory signal essential for T cell activation during antigen presentation, while binding with CTLA-4 negatively regulates T cell activation, diminishing the immune response. This interaction is critical for T-B cell crosstalk, T cell costimulation, autoantibody production, and Th2-mediated Ig production. The kinetics of CD86 upregulation upon stimulation suggest its significant contribution during the primary phase of an immune response. CD86 and CD80 have distinct roles in T helper cell differentiation, and insufficient co-stimulation involving these molecules can induce tolerance. Alternative splicing of CD86 results in two transcript variants encoding different isoforms, with additional variants described but not fully sequenced. Dysfunction in CD86 is associated with diseases such as gallbladder squamous cell carcinoma and myocarditis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B lymphocyte activation antigen B72; B-lymphocyte activation antigen B7-2; CD28 antigen ligand 2; CD86; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen); CTLA-4 counter-receptor B7.2; Early T-cell co-stimulatory molecule 1; MGC34413; unnamed protein product
Gene Aliases: B7-2; B7.2; B70; BU63; CD28LG2; CD86 v6; FUN-1; LAB72
UniProt ID: (Human) P42081
Entrez Gene ID: (Human) 942
positive regulation of immunoglobulin production
immune response
signal transduction
cell surface receptor signaling pathway
positive regulation of cell proliferation
positive regulation of signal transduction
T cell costimulation
positive regulation of interleukin-2 production
positive regulation of interleukin-4 production
positive regulation of lymphotoxin A production
positive regulation of T cell proliferation
T cell activation
B cell activation
negative regulation of T cell proliferation
positive regulation of T-helper 2 cell differentiation
positive regulation of transcription, DNA-templated
lymphocyte activation
positive regulation of immune response
positive regulation of T cell receptor signaling pathway
regulation of T cell activation
cellular response to lipopolysaccharide
positive regulation of NIK/NF-kappaB signaling
regulation of leukocyte cell-cell adhesion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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