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Invitrogen
FBXL10 Recombinant Rabbit Monoclonal Antibody (PSH05-38)
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FIGURE: 1 / 12
FBXL10 Antibody (MA5-56496) in ICC/IF
Immunocytochemistry analysis of FBXL10 with NIH/3T3 cells. Cells were fixed in 4% paraformaldehyde (20 min, room temp), permeabilized with 0.1% Triton X-100 in PBS (5 min, room temp), then blocked with 1% BSA in 10% negative goat serum (1 hr, room temp). Next they were incubated with FBXL10 Recombinant Monoclonal Antibody (Product # MA5-56496)at a dilution of 1:2,000 in 1% BSA in PBST overnight at 4 &(8)451;. Followed by Goat Anti-Rabbit IgG H&L at a dilution of 1:1,000. DAPI was used to stain the cell nuclei (blue).
Product Details
MA5-56496
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
PSH05-38
Immunogen
Recombinant protein within mouse KDM2B aa 681-920/1,309.
Conjugate
Form
Liquid
Concentration
1.03 mg/mL
Amount
103 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs, which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: [Histone-H3]-lysine-36 demethylase 1B; CXXC-type zinc finger protein 2; F-box and leucine-rich repeat protein 10; F-box protein containing leucine repeats 10; F-box protein FBL10; F-box/LRR-repeat protein 10; JEMMA (Jumonji domain, EMSY-interactor, methyltransferase motif) protein; JmjC domain-containing histone demethylation protein 1B; jumonji C domain-containing histone demethylase 1B; Jumonji domain-containing EMSY-interactor methyltransferase motif protein; lysine (K)-specific demethylase 2B; Lysine-specific demethylase 2B; Protein JEMMA; Protein-containing CXXC domain 2; unnamed protein product
Gene Aliases: CXXC2; FBL10; FBXL10; JHDM1B; KDM2B; Kiaa3014; NDY1; PCCX2
UniProt ID: (Human) Q8NHM5, (Mouse) Q6P1G2
Entrez Gene ID: (Human) 84678, (Rat) 304495, (Mouse) 30841
RNA polymerase II core promoter proximal region sequence-specific DNA binding
DNA binding
transcription cofactor activity
RNA binding
protein binding
zinc ion binding
oxidoreductase activity
rRNA binding
histone demethylase activity
unmethylated CpG binding
metal ion binding
dioxygenase activity
histone demethylase activity (H3-K36 specific)
histone H3-di/monomethyl-lysine-36 demethylase activity
molecular_function
negative regulation of transcription from RNA polymerase II promoter
chromatin organization
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
spermatogenesis
midbrain-hindbrain boundary morphogenesis
fourth ventricle development
lateral ventricle development
third ventricle development
initiation of neural tube closure
positive regulation of cell growth
forebrain development
midbrain development
hindbrain development
negative regulation of neuron apoptotic process
embryonic camera-type eye morphogenesis
positive regulation of stem cell population maintenance
negative regulation of neural precursor cell proliferation
biological_process
histone H2A monoubiquitination
transcription, DNA-templated
regulation of transcription, DNA-templated
chromatin modification
histone demethylation
oxidation-reduction process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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