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Invitrogen

Nogo-A/B (Biosimilar) Recombinant Human Monoclonal Antibody

View all (6) Nogo-A/B antibodies

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Product Details

MA5-59765

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

Assay-dependent
-

ELISA (ELISA)

Assay-dependent
-

Functional Assay (Functional)

Assay-dependent
-

Surface plasmon resonance (SPR)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Human / IgG1

Expression System

CHO cells

Class

Recombinant Monoclonal

Type

Antibody

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

25mM histidine, pH 6.2, with 8% sucrose, 0.01% Tween 80

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Dry ice (international)

RRID

AB_3682784

Product Specific Information

For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.

This antibody can also be cross referenced by the term NG-101.

Target Information

Nogo-B is a novel myelin-associated, intermediate-length splice variant of Nogo belonging to the reticulon family. It is a multidomain neurite growth inhibitory protein containing several discrete regions with growth inhibitory functions and is a component of the CNS myelin that prevents axonal regeneration in the adult vertebrate CNS. Nogo-B along with NGBR mediated chemotaxis in HUVECs and induced tube formation in 3-dimensional cultures. It is mostly found in intact blood vessels, smooth muscle cells, and endothelial cell, with its N terminus oriented extracellularly and is a regulator of vascular homeostasis and remodeling. It plays an important role in sporadic and familial amyotrophic lateral sclerosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ASY; Foocen; Human NogoA; MGC116054; My043 protein; neurite growth inhibitor 220; Neurite outgrowth inhibitor; Neuroendocrine-specific protein; Neuroendocrine-specific protein C homolog; Nogo protein; NOGO-A; RTN4-A; NOGO-B; RTN4-B1; NOGO-C; RTN4-C; NSP; reticulon; reticulon 5; Reticulon-4; Reticulon-5; RTN-x; RTN4-Aa; RTN4-Ab; RTN4-B2; RTN4-D; RTN4-E; RTN4-F; RTN4-G; RTN4a; RTN4b; RTN4c; unnamed protein product

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Gene Aliases: ASY; KIAA0886; My043; Nbla00271; Nbla10545; NI220/250; NOGO; NSP; NSP-CL; RTN-X; RTN4; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C; SP1507

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UniProt ID: (Human) Q9NQC3

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Entrez Gene ID: (Human) 57142

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Function(s)
RNA binding protein binding ubiquitin protein ligase binding protein homodimerization activity cadherin binding metal ion binding
Process(es)
blastocyst formation leukocyte migration involved in inflammatory response apoptotic process endoplasmic reticulum organization nervous system development axonal fasciculation brain development positive regulation of epithelial cell migration cerebral cortex radial glia guided migration central nervous system vasculogenesis neuron differentiation negative regulation of cell growth regulation of cell migration negative regulation of axon extension positive regulation of mammary gland epithelial cell proliferation positive regulation of toll-like receptor 9 signaling pathway positive regulation of Rac protein signal transduction cell migration involved in vasculogenesis regulation of apoptotic process positive regulation of angiogenesis modulation of synaptic transmission protein stabilization nuclear pore complex assembly positive regulation of protein kinase B signaling regulation of nervous system development cardiac epithelial to mesenchymal transition positive regulation of macrophage cytokine production protein localization to lysosome cellular response to hypoxia endoplasmic reticulum tubular network organization endoplasmic reticulum tubular network assembly cellular sphingolipid homeostasis cell adhesion involved in sprouting angiogenesis regulation of postsynapse assembly negative regulation of beta-amyloid formation positive regulation of neutrophil migration positive regulation of macrophage migration positive regulation of protein localization to endoplasmic reticulum positive regulation of ERBB3 signaling pathway positive regulation of artery morphogenesis endoplasmic reticulum tubular network membrane organization regulation of branching morphogenesis of a nerve positive regulation of hepatocyte proliferation negative regulation of vasculogenesis
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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