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Invitrogen

Her-2 (ErbB2) Recombinant Rabbit Monoclonal Antibody (205), HRP

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Her-2 (ErbB2) Recombinant Rabbit Monoclonal Antibody (205), HRP

Product Details

MA5-60192

Applications
Tested Dilution
Publications

ELISA (ELISA)

0.1-1 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

205

Immunogen

Recombinant Human HER2/ERBB2 protein (Met1-Thr652).
3D Epitope / Immunogen

Conjugate

HRP HRP HRP

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3699554

Target Information

ErbB2 (HER2) is a receptor tyrosine kinase that is overexpressed in some breast tumors. Herceptin, used in treatment of metastatic Her2-positive cancer, is monoclonal antibody targeting this kinase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: approximately 68 kDa secreted autoinhibitor glycoprotein; c-erb B2/neu protein; CD antigen CD340; erb-b2; erbb 2; ErbB2 (pTyr1139); ErbB2 (pY1139); ErbB2 phospho Y1139; her 2; HER2 receptor; HER2/neu receptor; herstatin; human epidermal growth factor receptor 2; metas; metastatic lymph node gene 19 protein; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; phospho ErbB2; proto-oncogene c-ErbB-2; proto-oncogene Neu; tyrosine kinase-type cell surface receptor HER2; unnamed protein product; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

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Gene Aliases: c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu; HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2

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UniProt ID: (Human) P04626

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Entrez Gene ID: (Human) 2064

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Function(s)
RNA polymerase I core binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane signaling receptor activity receptor binding protein binding ATP binding coreceptor activity growth factor binding receptor tyrosine kinase binding identical protein binding ErbB-3 class receptor binding protein heterodimerization activity
Process(es)
protein phosphorylation signal transduction cell surface receptor signaling pathway enzyme linked receptor protein signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway epidermal growth factor receptor signaling pathway cell proliferation Schwann cell development peptidyl-tyrosine phosphorylation neuron differentiation positive regulation of cell growth regulation of microtubule-based process positive regulation of Rho protein signal transduction intracellular signal transduction ERBB signaling pathway ERBB2 signaling pathway ERBB2-ERBB3 signaling pathway ERBB2-EGFR signaling pathway ERBB2-ERBB4 signaling pathway wound healing regulation of cell proliferation negative regulation of apoptotic process positive regulation of MAP kinase activity positive regulation of MAPK cascade protein kinase B signaling positive regulation of translation regulation of angiogenesis positive regulation of cell adhesion positive regulation of transcription from RNA polymerase I promoter positive regulation of JNK cascade positive regulation of epithelial cell proliferation regulation of ERK1 and ERK2 cascade cellular response to growth factor stimulus cellular response to epidermal growth factor stimulus semaphorin-plexin signaling pathway positive regulation of protein targeting to membrane neurotransmitter receptor localization to postsynaptic specialization membrane
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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