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Invitrogen
Nectin 2 Recombinant Rabbit Monoclonal Antibody (005), PE
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Product Details
MA5-60203
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
005
Immunogen
Recombinant Human CD112/Nectin-2 protein (Met1-Leu360).
Conjugate
PE
PE
PE
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Concentration
0.1 mg/mL
Purification
Protein A
Storage buffer
PBS with 0.5% BSA
Contains
0.03% ProClin 300
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: herpesvirus entry protein B; HveB; poliovirus receptor-like 2; poliovirus receptor-related 2 (herpesvirus entry mediator B); PVRL2; unnamed protein product
Gene Aliases: CD112; HVEB; PRR2; PVRL2; PVRR2
UniProt ID: (Human) Q92692
Entrez Gene ID: (Human) 5819
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
positive regulation of immunoglobulin mediated immune response
homophilic cell adhesion via plasma membrane adhesion molecules
signal transduction
spermatid development
fusion of virus membrane with host plasma membrane
positive regulation of mast cell activation
natural killer cell mediated cytotoxicity
susceptibility to natural killer cell mediated cytotoxicity
adhesion of symbiont to host
negative regulation of natural killer cell mediated cytotoxicity
positive regulation of natural killer cell mediated cytotoxicity
regulation of viral entry into host cell
viral entry into host cell
coreceptor-mediated virion attachment to host cell
positive regulation of T cell receptor signaling pathway
susceptibility to T cell mediated cytotoxicity
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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