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Invitrogen

Caveolin 3 Recombinant Rabbit Monoclonal Antibody (23GB3040)

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View all (11) Caveolin 3 antibodies

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Caveolin 3 Recombinant Rabbit Monoclonal Antibody (23GB3040)

Product Details

MA553331

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:5,000
-

Immunocytochemistry (ICC/IF)

1:1,000
-

Flow Cytometry (Flow)

1:2,000
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293F

Class

Recombinant Monoclonal

Type

Antibody

Clone

23GB3040

Immunogen

A synthesized peptide derived from Caveolin-3 (1-60AA).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.80 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3247804

Target Information

Caveolin-3 (CAV3) acts as a scaffolding protein within the caveolar membrane. It interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-3 may also regulate voltage-gated potassium channels. It also plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Caveolin-3 also mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae. Mutations in the gene can result in HyperCKmia, rippling muscle disease 2, cardiomyopathy, long QT syndrome 9, sudden infant death syndrome, and myopathy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CAV; Caveolin-3; cavolin 3; contains K15N mutation; M-caveolin; MGC126100; MGC126101; MGC126129; unnamed protein product

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Gene Aliases: CAV3; LGMD1C; LQT9; MPDT; RMD2; VIP-21; VIP21

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UniProt ID: (Human) P56539, (Rat) P51638

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Entrez Gene ID: (Human) 859, (Rat) 29161

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Function(s)
calcium channel regulator activity protein binding sodium channel regulator activity potassium channel inhibitor activity enzyme binding alpha-tubulin binding ion channel binding macromolecular complex binding nitric-oxide synthase binding binding, bridging connexin binding protein C-terminus binding protein complex binding protein complex scaffold scaffold/adaptor protein
Process(es)
MAPK cascade response to hypoxia plasma membrane repair regulation of heart rate response to ischemia cardiac muscle hypertrophy triglyceride metabolic process calcium ion transport endocytosis plasma membrane organization actin filament organization positive regulation of cytosolic calcium ion concentration muscle organ development myoblast fusion regulation of heart contraction protein localization positive regulation of cell proliferation negative regulation of cardiac muscle hypertrophy positive regulation of myotube differentiation regulation of skeletal muscle contraction myotube differentiation regulation of transforming growth factor beta receptor signaling pathway cell differentiation positive regulation of microtubule polymerization cytoplasmic microtubule organization membrane raft organization T-tubule organization detection of muscle stretch regulation of signal transduction by receptor internalization regulation of membrane potential glucose homeostasis cholesterol homeostasis negative regulation of MAPK cascade negative regulation of cell size regulation of nerve growth factor receptor activity regulation of cytosolic calcium ion concentration nucleus localization establishment of localization in cell regulation of protein kinase B signaling regulation of calcium ion transport negative regulation of calcium ion transport cardiac muscle cell development regulation of cardiac muscle contraction negative regulation of sarcomere organization regulation of ventricular cardiac muscle cell membrane repolarization heart trabecula formation regulation of ventricular cardiac muscle cell membrane depolarization regulation of branching involved in mammary gland duct morphogenesis negative regulation of cell growth involved in cardiac muscle cell development caveola assembly protein localization to plasma membrane ventricular cardiac muscle cell action potential regulation of calcium ion import regulation of cardiac muscle cell action potential involved in regulation of contraction regulation of p38MAPK cascade regulation of membrane depolarization during cardiac muscle cell action potential negative regulation of membrane depolarization during cardiac muscle cell action potential negative regulation of potassium ion transmembrane transport regulation of sodium ion transmembrane transport cellular response to ionomycin negative regulation of protein localization to cell surface positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of caveolin-mediated endocytosis negative regulation of protein kinase activity cell growth negative regulation of MAP kinase activity muscle cell cellular homeostasis negative regulation of nitric-oxide synthase activity establishment of protein localization to plasma membrane negative regulation of potassium ion transmembrane transporter activity regulation of calcium ion transmembrane transporter activity regulation of sodium ion transmembrane transporter activity
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