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Invitrogen
N-cadherin Monoclonal Antibody (8C11), Alexa Fluor™ 647
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FIGURE: 1 / 2
N-cadherin Antibody (MA562293) in Flow
Flow cytometry (surface staining) of N-cadherin in HeLa cells. Samples were stained with N-cadherin monoclonal antibody (Product # MA562293) using a dilution of 5 µg/mL. Separation of stained HeLa cells (red-filled) from HeLa cells stained using mouse IgG1 isotype control (MOPC-21) Alexa Fluor® 647 antibody (5 µg/mL, black-dashed).
Product Details
MA562293
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
8C11
Immunogen
Bacterially expressed extracellular domain of human CD325.
Conjugate
Excitation/Emission Max
650/671 nm
View spectra
Form
Liquid
Purification
Size-exclusion chromatography
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
15mM sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
N-cadherin is a 140 kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin. Further, N-cadherin is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cadherin 2, type 1, N-cadherin (neuronal); Cadherin-2; Cadherin-N; Cadherin2; calcium-dependent adhesion protein, neuronal; CD325; CDw325; CDw325 antigen; N-cadherin; N-cadherin 1; Neural cadherin; unnamed protein product
Gene Aliases: ACOGS; ADHD8; ARVD14; CD325; CDH2; CDHN; CDw325; N-cadherin; NCAD
UniProt ID: (Human) P19022, (Mouse) P15116
Entrez Gene ID: (Human) 1000, (Mouse) 12558
RNA binding
calcium ion binding
protein binding
beta-catenin binding
enzyme binding
protein kinase binding
protein phosphatase binding
identical protein binding
alpha-catenin binding
gamma-catenin binding
cadherin binding
metal ion binding
protein complex binding
nitric-oxide synthase binding
cadherin
cell morphogenesis
type B pancreatic cell development
cell-cell junction assembly
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
synapse assembly
glial cell differentiation
neural crest cell development
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cell migration
telencephalon development
cerebral cortex development
adherens junction organization
detection of muscle stretch
positive regulation of MAPK cascade
cell-cell adhesion mediated by cadherin
blood vessel morphogenesis
brain morphogenesis
homeostasis of number of cells
striated muscle cell differentiation
radial glial cell differentiation
neuroepithelial cell differentiation
regulation of oligodendrocyte progenitor proliferation
protein localization to plasma membrane
negative regulation of canonical Wnt signaling pathway
mesenchymal cell migration
synaptic vesicle clustering
neuroligin clustering involved in postsynaptic membrane assembly
neuronal stem cell population maintenance
cell-cell adhesion
regulation of postsynaptic density protein 95 clustering
positive regulation of synaptic vesicle clustering
regulation of signal transduction
single organismal cell-cell adhesion
regulation of myelination
regulation of protein localization
regulation of Rho protein signal transduction
regulation of axonogenesis
protein heterooligomerization
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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