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Invitrogen
HELIOS Monoclonal Antibody (22F6), Alexa Fluor™ 647
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FIGURE: 1 / 3
HELIOS Antibody (MA562378) in Flow
Flow cytometry (intracellular staining) of HELIOS in human peripheral whole blood. Samples were stained with HELIOS monoclonal antibody (Product # MA562378) using a dilution of 4 µL reagent/100 µL of peripheral whole blood. Separation of human CD3 positive Helios positive T cells (red-filled) from human neutrophil granulocytes (black-dashed).
Product Details
MA562378
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Armenian hamster
/ IgG
Class
Monoclonal
Type
Antibody
Clone
22F6
Immunogen
Peptide coresponding to the amino acids 51-107 of Helios.
Conjugate
Excitation/Emission Max
650/671 nm
View spectra
Form
Liquid
Purification
Size-exclusion chromatography
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
15mM sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ikaros family zinc finger protein 2; transcription factor; unnamed protein product; zinc finger DNA binding protein Helios; Zinc finger protein Helios; zinc finger protein, subfamily 1A, 2 (Helios)
Gene Aliases: A730095J18Rik; ANF1A2; HELIOS; ICHAD; IKZF2; IMDIA; Zfpn1a2; ZNF1A2; ZNFN1A2
UniProt ID: (Human) Q9UKS7, (Mouse) P81183
Entrez Gene ID: (Human) 22807, (Mouse) 22779
RNA polymerase II core promoter proximal region sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
zinc ion binding
identical protein binding
metal ion binding
nucleic acid binding
protein homodimerization activity
protein heterodimerization activity
C2H2 zinc finger transcription factor
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