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Invitrogen
CX3CR1 Monoclonal Antibody (2A9-1)
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FIGURE: 1 / 6
CX3CR1 Antibody (MA562397) in Flow
Flow cytometry (multicolor surface staining) of CX3CR1 in human leukocytes. Samples were stained with CX3CR1 monoclonal antibody (Product # MA562397) using a dilution of 0.33 µg/mL with anti-human CD14 (MEM-15) Pacific Blue™ antibody at 4 µL reagent/100 µL of peripheral whole blood.
Product Details
MA562397
Product Specifications
Species Reactivity
Human,
Non-human primate
Host/Isotype
Rat
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
2A9-1
Immunogen
Human CX3CR1 transfectants.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4
Contains
15mM sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human, mouse, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively. The encoded seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1. Recently, CX3CR1 was found to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by fractokine. CX3CR1 mediates leukocyte migration an d adhesion. CX3CR1 is expressed in a variety of human tissues and cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Beta chemokine receptor-like 1; C-X3-C CKR-1; chemokine (C-C) receptor-like 1; chemokine (C-X3-C motif) receptor 1; chemokine (C-X3-C) receptor 1; CMK-BRL-1; CMK-BRL1; Cx3c; CX3C chemokine receptor 1; Fractalkine receptor; G-protein coupled receptor 13; Scyd1; unnamed protein product; V28
Gene Aliases: CCRL1; CMKBRL1; CMKDR1; CX3CR1; GPR13; GPRV28; V28
UniProt ID: (Human) P49238
Entrez Gene ID: (Human) 1524
positive regulation of neuroblast proliferation
adaptive immune response
microglial cell activation involved in immune response
immune system process
response to ischemia
chemotaxis
inflammatory response
immune response
cellular defense response
cell adhesion
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
cell-cell signaling
brain development
response to wounding
negative regulation of angiogenesis
cytokine-mediated signaling pathway
calcium-mediated signaling
central nervous system maturation
leukocyte chemotaxis
regulation of tumor necrosis factor production
negative regulation of interleukin-1 beta production
social behavior
autocrine signaling
positive regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
regulation of nitric oxide biosynthetic process
regulation of synaptic plasticity
host-mediated regulation of intestinal microbiota composition
regulation of neurogenesis
positive regulation of neurogenesis
modulation of synaptic transmission
leukocyte tethering or rolling
positive regulation of protein kinase B signaling
synapse maturation
cell chemotaxis
antifungal innate immune response
chemokine-mediated signaling pathway
cellular response to lipopolysaccharide
cellular response to cytokine stimulus
positive regulation of monocyte chemotaxis
synapse pruning
negative regulation of hippocampal neuron apoptotic process
multiple spine synapse organization, single dendrite
regulation of microglial cell migration
negative regulation of microglial cell mediated cytotoxicity
negative regulation of apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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