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Invitrogen
MAD2L2 Polyclonal Antibody
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FIGURE: 1 / 2
MAD2L2 Antibody (PA1-31766) in IHC (P)
Immunohistochemistry (Paraffin) analysis of MAD2L2 was performed in tumor cells of cancerous human kidney tissue using MAD2L2 Polyclonal Antibody (Product # PA1-31766). Tissue was formalin-fixed and paraffin embedded. Brown color indicates presence of protein, blue color shows cell nuclei.
Product Details
PA1-31766
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to an N-terminus region of Human MAD2L2.
Conjugate
Form
Liquid
Concentration
1.3 mg/mL
Amount
50 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 0.15M NaCl
Contains
0.01% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA1-31766 detects MAD2L2 from human samples.
Target Information
The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hREV7; MAD2 (mitotic arrest deficient, yeast, homolog)-like 2; MAD2 mitotic arrest deficient-like 2; MAD2-like protein 2; Mitotic arrest deficient 2-like protein 2; mitotic arrest deficient homolog-like 2; Mitotic spindle assembly checkpoint protein MAD2B; polymerase (DNA-directed), zeta 2, accessory subunit; REV7 homolog; RP3-330O12.4; similar to mitotic checkpoint protein hMAD2; spindle-assembly checkpoint protein homolog; unnamed protein product
Gene Aliases: FANCV; MAD2B; MAD2L2; POLZ2; REV7
UniProt ID: (Human) Q9UI95
Entrez Gene ID: (Human) 10459
negative regulation of transcription from RNA polymerase II promoter
regulation of cell growth
somatic diversification of immunoglobulins involved in immune response
DNA repair
double-strand break repair
cellular response to DNA damage stimulus
actin filament organization
mitotic spindle assembly checkpoint
regulation of epithelial to mesenchymal transition
negative regulation of epithelial to mesenchymal transition
negative regulation of transcription by competitive promoter binding
positive regulation of peptidyl-serine phosphorylation
negative regulation of protein catabolic process
error-prone translesion synthesis
DNA damage response, signal transduction resulting in transcription
telomere maintenance in response to DNA damage
positive regulation of isotype switching
positive regulation of transcription, DNA-templated
cell division
negative regulation of canonical Wnt signaling pathway
negative regulation of ubiquitin protein ligase activity
negative regulation of double-strand break repair via homologous recombination
negative regulation of cell-cell adhesion mediated by cadherin
positive regulation of double-strand break repair via nonhomologous end joining
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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