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Immunohistochemical analysis of MAD2L2 showing strong nuclear and cytoplasmic staining of tumor cells in formalin-fixed, paraffin-embedded cancerous human kidney tissue using a MAD2L2 polyclonal antibody (Product # PA1-31766). Brown color indicates presence of protein, blue color shows cell nuclei.
|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||synthetic peptide TLTRQDLNFGQV, corresponding to amino acids 3-14 of Human Mad2L2.|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.02M potassium phosphate, pH 7.2, with 0.15M NaCl|
|Contains||0.01% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||Assay-Dependent|
|Western Blot (WB)||1:500|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-31766 detects MAD2L2 from human samples.
PA1-31766 has been successfully used in Western blot applications.
The PA1-31766 immunogen is: Synthetic peptide: TLTRQDLNFGQV, corresponding to amino acids 3-14 of Human Mad2L2.
The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
hREV7; MAD2 (mitotic arrest deficient, yeast, homolog)-like 2; MAD2-like protein 2; MAD2B; Mitotic arrest deficient 2-like protein 2; mitotic arrest deficient homolog-like 2; Mitotic spindle assembly checkpoint protein MAD2B; polymerase (DNA-directed), zeta 2, accessory subunit; REV7; REV7 homolog; RP3-330O12.4
MAD2B; MAD2L2; POLZ2; REV7