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This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.
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Protein Aliases: bHLHc13; Class C basic helix-loop-helix protein 13; FLJ35523; Max dimerization protein 3; Max dimerizer 3; Max-associated protein 3; Max-interacting transcriptional repressor MAD3; MGC2383; Myx
Gene Aliases: BHLHC13; MAD3; MXD3; MYX
UniProt ID: (Human) Q9BW11
Entrez Gene ID: (Human) 83463
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