Recommended positive controls: 293T, A431, HeLa, HepG2, mouse muscle, rat muscle.
Predicted reactivity: Mouse (98%), Rat (98%), Chicken (92%), Rhesus Monkey (100%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: avian musculoaponeurotic fibrosarcoma virus (v-maf) AS42 oncogene, protein G; basic leucine zipper transcription factor MafG; hMAF; MGC13090; MGC20149; Transcription factor MafG; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G; v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G; V-maf musculoaponeurotic fibrosarcoma oncogene homolog G
Gene Aliases: AA545192; C630022N07Rik; hMAF; MAFG