MAGEA11 is a member of the MAGEA gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 80% sequence identity between each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are expressed at a high level in a number of tumors of various histologic types, and are silent in normal tissues with the exception of testis and placenta. The MAGEA genes are clustered on chromosome Xq28. They may be implicated in some hereditary disorders, such as dyskeratosis congenita.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cancer/testis antigen 1.11; cancer/testis antigen family 1, member 11; CT1.11; MAGE-11 antigen; melanoma antigen family A, 11; melanoma antigen family A11; Melanoma-associated antigen 11
Gene Aliases: CT1.11; MAGE-11; MAGE11; MAGEA-11; MAGEA11
UniProt ID: (Human) P43364
Entrez Gene ID: (Human) 4110
Molecular Function: cell adhesion molecule