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Invitrogen
MAGEA2 Polyclonal Antibody
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FIGURE: 1 / 2
MAGEA2 Antibody (PA5-13151) in WB
Western blot analysis of MAGEA2 in A549 whole cell lysate. Samples were incubated with MAGEA2 polyclonal antibody (Product # PA5-13151) using a dilution of 1:2,000 followed by Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at a dilution of 1:10,000. Lysates/proteins: 20 µg per lane. Predicted band size: 35 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
Product Details
PA5-13151
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 81-108 amino acids from the N-terminal region of human MAGEA2
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation, Size-exclusion - Dialysis, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
MAGEA2 is a member of the MAGEA gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 80% sequence identity between each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are expressed at a high level in a number of tumors of various histologic types, and are silent in normal tissues with the exception of testis and placenta. The MAGEA genes are clustered on chromosome Xq28. They may be implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cancer/testis antigen 1.2; cancer/testis antigen family 1, member 2; CT1.2; MAGE-2 antigen; melanoma antigen 2; melanoma antigen family A, 2; melanoma antigen family A2; Melanoma-associated antigen 2; MGC131923; unnamed protein product
Gene Aliases: CT1.2; MAGE2; MAGEA2; MAGEA2A; MAGEA2B
UniProt ID: (Human) P43356
Entrez Gene ID: (Human) 4101
negative regulation of transcription from RNA polymerase II promoter
protein catabolic process
negative regulation of protein sumoylation
positive regulation of ubiquitin-protein transferase activity
signal transduction by p53 class mediator
cellular senescence
negative regulation of protein acetylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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