|Flow Cytometry (Flow)||1:10-1:50|
|Immunohistochemistry (Paraffin) (IHC (P))||1:10-1:50|
|Western Blot (WB)||1:1000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 283-314 amino acids from the C-terminal region of human MAGEA3|
|Purification||Ammonium sulfate precipitation, Size-exclusion - Dialysis|
|Contains||0.09% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
MAGEA3 is a member of the MAGEA gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 80% sequence identity between each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are expressed at a high level in a number of tumors of various histologic types, and are silent in normal tissues with the exception of testis and placenta. The MAGEA genes are clustered on chromosome Xq28. They may be implicated in some hereditary disorders, such as dyskeratosis congenita.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Antigen MZ2-D; Cancer/testis antigen 1.3; cancer/testis antigen family 1, member 3; CT1.3; MAGE-3 antigen; MAGE3; melanoma antigen family A, 3; melanoma antigen family A3; Melanoma-associated antigen 3
Gene Aliases: CT1.3; HIP8; HYPD; MAGE3; MAGEA3; MAGEA6
UniProt ID: (Human) P43357
Entrez Gene ID: (Human) 4102
Molecular Function: cell adhesion molecule
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