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Product Details
APZ-052-200UL
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)ENSYRSEVKARQDVK, corresponding to amino acid residues 1066-1080 of mouse MAGI2, Intracellular, C-terminus
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. Florindo C.S., Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases. The MGC Project Team, Genome Res. 14:2121-2127(2004). Devroe E., J. Biol. Chem. 279:24444-24451(2004).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activin receptor interacting protein 1; Activin receptor-interacting protein 1; Acvrip1; AIP-1; Atrophin-1-interacting protein 1; Atrophin-1-interacting protein A; MAGI-2; Membrane-associated guanylate kinase inverted 2; Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2; S-SCAM; Synaptic-scaffolding molecule
Gene Aliases: Acvri1; ACVRINP1; ACVRIP1; AIP-1; AIP1; ARIP1; KIAA0705; MAGI-2; MAGI2; mKIAA0705; S-SCAM; SSCAM
UniProt ID: (Human) Q86UL8, (Rat) O88382, (Mouse) Q9WVQ1
Entrez Gene ID: (Human) 9863, (Rat) 113970, (Mouse) 50791
positive regulation of receptor internalization
glomerular filtration
signal transduction
negative regulation of cell proliferation
positive regulation of neuron projection development
phosphorylation
cytosolic transport
negative regulation of cell migration
positive regulation of phosphoprotein phosphatase activity
negative regulation of activin receptor signaling pathway
nerve growth factor signaling pathway
receptor clustering
protein heterooligomerization
negative regulation of protein kinase B signaling
SMAD protein signal transduction
mitotic cell cycle arrest
glomerular visceral epithelial cell development
cellular response to nerve growth factor stimulus
planar cell polarity pathway involved in axis elongation
neuroligin clustering involved in postsynaptic membrane assembly
positive regulation of synaptic vesicle clustering
nervous system development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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