PA5-28593 targets MAK in WB applications and shows reactivity with Human samples.
The PA5-28593 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 237 of Human MAK.
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The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. It is expressed almost exclusively in the testis, primarily in germ cells. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. There is, however, a study of the mouse homolog that has identified high levels of expression in developing sensory epithelia so its function may be more generalized.
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Protein Aliases: dJ417M14.2; Male germ cell-associated kinase; male germ cell-associated kinase retinal-enriched isoform; serine/threonine protein kinase MAK; Serine/threonine-protein kinase MAK; testicular secretory protein Li 28
Gene Aliases: MAK; RP62
UniProt ID: (Human) P20794
Entrez Gene ID: (Human) 4117