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Invitrogen
MAL Polyclonal Antibody
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Product Details
PA5-141004
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide within mouse MAL aa 103-146.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
MAL, a nonglycosylated integral membrane proteolipid, has been identified as a major internal component of glycolipid-enriched membrane (GEM) microdomains. MAL is the first integral membrane proteolipid component to have been shown as a necessary element in the cellular apical sorting apparatus for newly synthesized proteins. In its steady state this highly hydrophobic proteolipid, resides predominantly in the apical zone of polarized epithelial cells. It has also been shown in itinerant protein cycling between the plasma membrane and endosomes and in other cells. This 17-kDa proteolipid contains four putative transmembrane domains. These domains along with its protein trafficking properties are defined by the specific signals delegated by its specific amino acid sequence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 17 kDa myelin vesicular protein; MAL; MAL protein; mal, T-cell differentiation protein; MAL-a; MAL-b; MAL-c; MAL-dex; MVP17; Myelin and lymphocyte protein; myelin and lymphocyte protein, T-cell differentiation protein; NS 3; T-lymphocyte maturation-associated protein; unnamed protein product
Gene Aliases: HLD28; MAL; MALGENE; Mpv17; MVP17; VIP17
UniProt ID: (Human) P21145, (Mouse) O09198, (Rat) Q64349
Entrez Gene ID: (Human) 4118, (Mouse) 17153, (Rat) 25263
membrane raft polarization
protein localization to paranode region of axon
apoptotic process
central nervous system development
central nervous system myelination
cell differentiation
myelination
apical protein localization
protein insertion into plasma membrane
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
intracellular protein transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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