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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues 43-57 E(43) L L D Q A P E G R G W R R L(57) of human MALT1.|
|Storage buffer||PBS with 0.2% gelatin|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||0.5-2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MALT-1 was independently identified as a member of the human paracaspase family and an interacting partner of B cell lymphoma. Two alternatively spliced transcript variants encoding different isoforms (a and b) have been described for the MALT-1 gene. Human MALT isoform a is an amino acid protein of 824 amino acids, and human MALT-2 isoform b is an amino acid protein of 813 amino acids. MALT-1 is thought to play a role in NFkappaB signaling by enchancing NF kappaB activation through interaction with BCL-10. Interaction between MALT-1 and BCL-10 mediates IKK activation in vitro through facilitating the ubiquitination of NEMO by the ubiquitin conjugating enzyme UBC13.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
caspase-like protein; DKFZp434L132; MALT lymphoma-associated translocation; MALT1 protease; MLT; MLT1; mucosa associated lymphoid tissue lymphoma translocation gene 1; paracaspase; paracaspase 1; paracaspase-1
IMD12; MALT1; MLT; MLT1; PCASP1