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Invitrogen
MALT1 Polyclonal Antibody
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Product Details
PA5-114500
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MALT1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human MALT1. The immunogen is located within amino acids 630 - 680 of MALT1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive controls that may be used include: EL4 Cell Lysate, Human Spleen Tissue Slide
Target Information
MALT1/Paracaspase (MALT1) was independently identified as a member of the human paracaspase family and an interacting partner of B-cell lymphoma (Uren et al., 2000). MALT1 is a caspase-like protein that contains an N-terminal death domain, two Ig-like domains, and a C-terminal caspase-like domain. It binds to Bcl10 through its Ig-like domains and cooperates with Bcl10 to activate NF-kappaB.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: caspase-like protein; DKFZp434L132; MALT lymphoma-associated translocation; malt-1; malt1; MALT1 paracaspase; MALT1 protease; MALT1; MLT1; mucosa associated lymphoid tissue lymphoma translocation gene 1; Mucosa-associated lymphoid tissue lymphoma translocation protein 1; Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog; Paracaspase; paracaspase-1; unnamed protein product
Gene Aliases: A630046N12; D430033E09Rik; IMD12; MALT1; MLT; MLT1; PCASP1
UniProt ID: (Human) Q9UDY8, (Mouse) Q2TBA3
Entrez Gene ID: (Human) 10892, (Rat) 307366, (Mouse) 240354
protease binding
endopeptidase activity
cysteine-type endopeptidase activity
ubiquitin-protein transferase activity
protein binding
peptidase activity
hydrolase activity
kinase activator activity
small molecule binding
identical protein binding
endopeptidase activator activity
molecular_function
signal transducer activity
protein self-association
cysteine protease
B-1 B cell differentiation
immune system process
positive regulation of immune effector process
positive regulation of T cell cytokine production
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
proteolysis
defense response
response to fungus
regulation of signal transduction
positive regulation of protein ubiquitination
lipopolysaccharide-mediated signaling pathway
positive regulation of interleukin-1 beta production
positive regulation of interleukin-2 production
T cell proliferation
B cell activation
regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
T cell receptor signaling pathway
regulation of T cell receptor signaling pathway
positive regulation of T cell activation
nuclear export
positive regulation of multicellular organismal process
proteolysis involved in cellular protein catabolic process
cellular response to lipopolysaccharide
positive regulation of T-helper 17 cell differentiation
response to molecule of bacterial origin
activation of NF-kappaB-inducing kinase activity
biological_process
protein ubiquitination
positive regulation of NF-kappaB transcription factor activity
protein oligomerization
apoptotic process
I-kappaB kinase/NF-kappaB signaling
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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