This antibody is predicted to react with mouse and horse based on sequence homology.
This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FLJ53540, KIAA0200, Mam-1, Mam1, mastermind homolog; Mam-1; MAML1; mastermind homolog; mastermind-like 1; Mastermind-like protein 1; mastermind-like transcriptional coactivator 1
Gene Aliases: KIAA0200; Mam-1; Mam1; MAML1
UniProt ID: (Human) Q92585
Molecular Function: transcription factor