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Product Details
PA5-104494
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human MAN1B1(Accession Q9UKM7), corresponding to amino acid residues V135-A185.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2853795
Product Specific Information
Antibody detects endogenous levels of total MAN1B1.
Target Information
Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man9GlcNAc2 to produce Man8GlcNAc2, but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man5-6GlcNAc2. Tremblay L.O., Glycobiology 9:1073-1078(1999) [PubMed: 10521544]. Gonzalez D.S., J. Biol. Chem. 274:21375-21386(1999) [PubMed: 10409699]. Clark H.F., Genome Res. 13:2265-2270(2003) [PubMed: 12975309].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3.2.1.113; endoplasmic Reticulum Class I alpha-mannosidase; Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase 1; ER alpha 1,2-mannosidase; ER alpha-1,2-mannosidase; ER mannosidase 1; ERMan1; Man9GlcNAc2-specific processing alpha-mannosidase; Man9GlcNAc2-specific-processing alpha-mannosidase; Mannosidase alpha class 1B member 1; mannosidase, alpha, class 1B, member 1; RP11-350O14.2
Gene Aliases: E430019H13Rik; ERMAN1; ERManI; Gm108; MAN1B1; MANA-ER; MRT15; RGD1563595; UNQ747/PRO1477
UniProt ID: (Human) Q9UKM7, (Rat) B2GUY0, (Mouse) A2AJ15
Entrez Gene ID: (Human) 11253, (Rat) 499751, (Mouse) 227619
alpha-mannosidase activity
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
calcium ion binding
lytic transglycosylase activity
mannosidase activity
mannosyl-oligosaccharide mannosidase activity
galactosidase activity
glucosidase activity
trehalase activity
fucosidase activity
hexosaminidase activity
amylase activity
hydrolase activity
hydrolase activity, acting on glycosyl bonds
dextrin alpha-glucosidase activity
starch alpha-glucosidase activity
beta-glucanase activity
beta-6-sulfate-N-acetylglucosaminidase activity
glucan endo-1,4-beta-glucosidase activity
protein modifying enzyme
N-glycan processing
oligosaccharide metabolic process
ER-associated ubiquitin-dependent protein catabolic process
protein alpha-1,2-demannosylation
trimming of terminal mannose on B branch
endoplasmic reticulum mannose trimming
mannose trimming involved in glycoprotein ERAD pathway
protein glycosylation
metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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