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This gene encodes a glycosyl hydrolase that localizes to the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Alpha-mannosidase 2; AMan II; Golgi alpha-mannosidase II; golgi integral membrane protein 7; Mannosidase alpha class 2A member 1; mannosidase, alpha type II; mannosidase, alpha, class 2A, member 1; Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
Gene Aliases: AMan II; GOLIM7; MAN2A1; MANA2; MANII
UniProt ID: (Human) Q16706
Entrez Gene ID: (Human) 4124
Molecular Function:
glycosidase
hydrolase
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