This gene encodes a glycosyl hydrolase that localizes to the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus.
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Protein Aliases: Alpha-mannosidase 2; alpha-mannosidase II; AMan II; Golgi alpha-mannosidase II; golgi integral membrane protein 7; MAN II; mannosidase 2, alpha 1; mannosidase alpha 2; Mannosidase alpha class 2A member 1; mannosidase, alpha type II; mannosidase, alpha, class 2A, member 1; Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
Gene Aliases: AMan II; GOLIM7; MAN2A1; Mana-2; MANA2; MANII; Manno; Map-2