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Proteintech
MAN2B2 Polyclonal Antibody
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Product Details
17697-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MAN2B2 Fusion Protein Ag11952 (660-1009 aa encoded by BC033307)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: VTEIRQYFY RNMTAQNYTY AIRSRLTHVP QGHDGELLCH RIEQEYQAGP LELNREAVLR TSTNLNSQQV IYSDNNGYQM QRRPYVSYVN NSIARNYYPM VQSAFMEDGK SRLVLLSERA HGISSQGNGQ VEVMLHRRLW NNFDWDLGYN LTLNDTSVVH PVLWLLLGSW SLTTALRQRS ALALQHRPVV LFGDLAGTAP KLPGPQQQEA VTLPPNLHLQ ILSIPGWRYS SNHTEHSQNL RKGHRGEAQA DLRRVLLRLY HLYEVGEDPV LSQPVTVNLE AVLQALGSVV AVEERSLTGT WDLSMLHRWS WRTGPGRHRG DTTSPSRPPG GPIITVHPKE IRTFFIHFQQ Q (660-1009 aa encoded by BC033307)
Target Information
The MAN2B2 (Mannosidase Alpha Class 2B Member 2) gene encodes an enzyme that is involved in the processing and modification of glycoproteins by hydrolyzing alpha-mannosidic linkages. Located on chromosome 4, the MAN2B2 protein is crucial for proper lysosomal function and is part of the glycosyl hydrolase family. Pathogenic variants in the MAN2B2 gene have been linked to a rare congenital disorder of glycosylation (CDG), known as MAN2B2-CDG, characterized by immune deficiency, developmental delay, stroke, and dysmorphic facial features. These mutations lead to an altered mannosylation profile, impacting glycoprotein processing and cellular functions. Studies have shown that reintroducing wild-type MAN2B2 can restore the normal mannosylation profile in patient cells, highlighting its therapeutic potential. Furthermore, recent research has identified circular RNA from this gene (circMAN2B2) that is implicated in the proliferation of hepatocellular carcinoma cells, suggesting a role in cancer biology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 135 kD alpha-D-mannosidase; 135 kDa alpha-D-mannosidase; Alpha-1,6-mannosidase; core-specific lysosomal alpha-1,6-Mannosidase; Epididymis-specific alpha-mannosidase; HMG17L3; mannosidase 2, alpha B2; Mannosidase alpha class 2B member 2; mannosidase, alpha, class 2B, member 2; NHC
Gene Aliases: Ab2-450; KIAA0935; MAN2B2; mKIAA0935
UniProt ID: (Human) Q9Y2E5, (Mouse) O54782
Entrez Gene ID: (Human) 23324, (Mouse) 17160, (Rat) 360955
alpha-mannosidase activity
zinc ion binding
mannan endo-1,6-alpha-mannosidase activity
carbohydrate binding
catalytic activity
hydrolase activity, hydrolyzing O-glycosyl compounds
lytic transglycosylase activity
mannosidase activity
mannosyl-oligosaccharide mannosidase activity
galactosidase activity
glucosidase activity
trehalase activity
fucosidase activity
hexosaminidase activity
amylase activity
hydrolase activity
hydrolase activity, acting on glycosyl bonds
dextrin alpha-glucosidase activity
starch alpha-glucosidase activity
metal ion binding
beta-glucanase activity
beta-6-sulfate-N-acetylglucosaminidase activity
glucan endo-1,4-beta-glucosidase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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