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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide: E(337) E E A L L Q A I L E G N F T(351) of the human MAP-1 protein|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:250 - 1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-4271 detects the MAP-1 (Modulator of Apoptosis) protein in human samples.
PA1-4271 has been successfully used in Western blot procedures. This antibody detects a ~36 kDa protein representing human MAP-1 in 293T cells.
PA1-4271 immunizing peptide corresponds to amino acid residues 337-351 of the human MAP-1 protein.
A novel Bax-associating protein, named MAP-1 (Modulator of Apoptosis), mediates caspase-dependent apoptosis in mammalian cells when overexpressed. MAP-1 homodimerizes and associates with the proapoptotic Bax and the prosurvival Bcl-2 and Bcl-X(L) of the Bcl-2 family in vitro and in vivo in mammalian cells. These data suggest that MAP-1 mediates apoptosis through a mechanism that involves binding to Bax.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
MAP1; paraneoplastic antigen like 4; Paraneoplastic antigen MA4; paraneoplastic Ma antigen family member 4
MAP-1; MOAP1; PNMA4