MAP2K4 (SEK1) is a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. MAP2K4 is phosphorylated and activated by MAP3K1/MEK.
Protein Aliases: C-JUN N-terminal kinase kinase 1; Dual specificity mitogen-activated protein kinase kinase 4; JNK kinase 1; JNK-activated kinase 1; JNK-activating kinase 1; JNKK; JNKK 1; MAP kinase kinase 4; MAP2K4delta; MAPK/ERK kinase 4; MAPKK 4; MEK 4; mitogen activated protein kinase kinase 4, variant 1; SAPK kinase 1; SAPK/ERK kinase 1; SAPK/Erk/kinase 1; SEK1; Stress-activated protein kinase kinase 1
Gene Aliases: JNKK; JNKK1; MAP2K4; MAPKK4; MEK4; MKK4; PRKMK4; SAPKK-1; SAPKK1; SEK1; SERK1; SKK1
Molecular Function: non-receptor serine/threonine protein kinase