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Proteintech
MAP3K6 Polyclonal Antibody
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Product Details
16212-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MAP3K6 Fusion Protein Ag9206 (1-307 aa encoded by BC015914)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MNLLLSYRD VQDYSAIIEL VETLQALPTC DVAEQHNVCF HYTFALNRRN RPGDRAKALS VLLPLVQLEG SVAPDLYCMC GRIYKDMFFS SGFQDAGHRE QAYHWYRKAF DVEPSLHSGI NAAVLLIAAG QHFEDSKELR LIGMKLGCLL ARKGCVEKMQ YYWDVGFYLG AQILANDPTQ VVLAAEQLYK LNAPIWYLVS VMETFLLYQH FRPTPEPPGG PPRRAHFWLH FLLQSCQPFK TACAQGDQCL VLVLEMNKVL LPAKLEVRGT DPVSTVTLSL LEPETQDIPS SWTFPVASIC GVSASKRD (1-307 aa encoded by BC015914)
Target Information
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MEKK6 activates the JNK, but not ERK or p38 kinase pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Apoptosis signal-regulating kinase 2; map3k6; MAPKKK6; MGC125653; MGC20114; mitogen activated protein kinase kinase kinase 6; Mitogen-activated protein kinase kinase kinase 6; OTTHUMP00000005063
Gene Aliases: ASK2; MAP3K6; MAPKKK6; MEKK6
UniProt ID: (Human) O95382
Entrez Gene ID: (Human) 9064, (Mouse) 53608, (Rat) 313022
nucleotide binding
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase kinase activity
protein binding
ATP binding
kinase activity
transferase activity
metal ion binding
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
MAPK cascade
protein phosphorylation
signal transduction
JNK cascade
p38MAPK cascade
activation of MAPKK activity
regulation of mitotic cell cycle
phosphorylation
signal transduction by protein phosphorylation
stress-activated protein kinase signaling cascade
regulation of apoptotic process
intracellular signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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