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The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
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Protein Aliases: MAP 4; MAP-4; Microtubule-associated protein 4
Gene Aliases: AA407148; MAP-4; MAP4; Mtap-4; Mtap4
UniProt ID: (Human) P27816, (Mouse) P27546, (Rat) Q5M7W5
Entrez Gene ID: (Human) 4134, (Mouse) 17758, (Rat) 367171
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