Peptide sequence: TVTSELAAVK IVKLDPGDDI SSLQQEITIL RECRHPNVVA YIGSYLRNDR
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 86%
The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1.
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Protein Aliases: B lymphocyte serine/threonine protein kinase; B lymphocyte serine/threonine-protein kinase; BL44; GC kinase; GCK; Germinal center kinase; germinal centre kinase (GC kinase); MAPK/ERK kinase kinase kinase 2; MEK kinase kinase 2; MEKKK 2; mitogen activated protein kinase kinase kinase kinase 2; Mitogen-activated protein kinase kinase kinase kinase 2; mitogen-activated protein kinase kinase kinase kinase 2-like; mitogen-activated protein kinase kinase kinase kinase 3-like; RAB8 interacting protein; Rab8-interacting protein; RAB8IP
Gene Aliases: AI385662; BL44; BOS_24870; dZ150L22.2; GCK; MAP4K2; map4k2l; map4k2l-2; map4k3l; RAB8IP; si:dz150l22.2; si:dz263j20.1; zgc:136670