Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:1,000-1:4,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
MAP4K3 Fusion Protein Ag6372 (537-873 aa encoded by BC071579) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.31 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: KIHCASSWI NPDTRDQYLI FGAEEGIYTL NLNELHETSM EQLFPRRCTW LYVMNNCLLS ISGKASQLYS HNLPGLFDYA RQMQKLPVAI PAHKLPDRIL PRKFSVSAKI PETKWCQKCC VVRNPYTGHK YLCGALQTSI VLLEWVEPMQ KFMLIKHIDF PIPCPLRMFE MLVVPEQEYP LVCVGVSRGR DFNQVVRFET VNPNSTSSWF TESDTPQTNV THVTQLERDT ILVCLDCCIK IVNLQGRLKS SRKLSSELTF DFQIESIVCL QDSVLAFWKH GMQGRSFRSN EVTQEISDST RIFRLLGSDR VVVLESRPTD NPTANSNLYI LAGHENSY (537-873 aa encoded by BC071579)
MAP4K3 encodes a member of the Ste20 family of serine/threonine protein kinases. The protein belongs to the subfamily that consists of members, such as germinal center kinase (GCK), that are characterized by an N-terminal catalytic domain and C-terminal regulatory domain. The kinase activity of the encoded protein can be stimulated by UV radiation and tumor necrosis factor-alpha. The protein specifically activates the c-Jun N-terminal kinase (JNK) signaling pathway. Evidence suggests that it functions upstream of mitogen-activated protein kinase kinase 1 (MEKK1). This gene previously was referred to as RAB8-interacting protein-like 1 (RAB8IPL1), but it has been renamed mitogen-activated protein kinase kinase kinase 3 (MAP4K3).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: germinal center kinase-like kinase; Germinal center kinase-related protein kinase; GLK; MAPK/ERK kinase kinase kinase 3; MEK kinase kinase 3; MEKKK 3; mitogen activated protein kinase kinase kinase kinase 3; Mitogen-activated protein kinase kinase kinase kinase 3
Gene Aliases: 4833416M01Rik; 4833416M07Rik; 9530052P13Rik; GLK; MAP4K3; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1
UniProt ID: (Human) Q8IVH8, (Mouse) Q99JP0, (Rat) Q924I2
Entrez Gene ID: (Human) 8491, (Mouse) 225028, (Rat) 170920
Molecular Function:
voltage-gated ion channel
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support
