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MAPK 8/9 Polyclonal Antibody

View all (13) JNK1/JNK2 antibodies

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Product Details

600-401-R00

Applications
Tested Dilution
Publications

Western Blot (WB)

0.5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MAPK8 affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region of human MAPK8.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS with 5mg BSA

Contains

0.05mg sodium azide, 0.05mg thimerosal

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

C-Jun N-terminal Kinase (JNK) is also known as Mitogen-activated protein kinase (MAPK8). It belongs to the MAPK superfamily of stress-activated protein kinases. MAPKs are Serine-threonine protein kinases that are activated in response to a variety of extracellular stimuli, and mediate signal transduction from the cell surface to the nucleus. JNK is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK pathways are activated by stress and inflammatory signals. JNK is expressed as ten different isoforms due to differential mRNA splicing. The predominant forms are JNK1 and JNK2.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: C-jun kinase; c-Jun N-terminal kinase 1; c-Jun N-terminal kinase 2; JNK 55; JNK-46; JNK-55; JNK/SAPK alpha; JNK1 beta1 protein kinase; Jun kinase; MAP kinase 8; MAP kinase 9; MAPK; MAPK 8; MAPK 9; mitogen activated protein kinase 8; mitogen activated protein kinase 9; Mitogen-activated protein kinase 8; Mitogen-activated protein kinase 9; OTTHUMP00000019552; p54 gamma; p54-alpha; Phospho-JNK; PRKM; protein kinase JNK1; protein kinase mitogen-activated 8; protein kinase, mitogen-activated 9; SAPK 1; SAPK gamma; SAPK-alpha; SAPK1a; SAPK1c; stress activated protein kinase alpha II; Stress-activated protein kinase 1a; Stress-activated protein kinase 1c; Stress-activated protein kinase JNK1; Stress-activated protein kinase JNK2

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Gene Aliases: AI849689; AI851083; JNK; JNK1; JNK2; MAPK8; MAPK9; p54aSAPK; PRKM8; PRKM9; SAPK; SAPK1; SAPK1A; SAPK1C

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UniProt ID: (Rat) P49185, (Mouse) Q91Y86, (Rat) P49186, (Mouse) Q9WTU6

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Entrez Gene ID: (Rat) 116554, (Mouse) 26419, (Rat) 50658, (Mouse) 26420

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity JUN kinase activity MAP kinase activity protein binding ATP binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups enzyme binding histone deacetylase regulator activity histone deacetylase binding transcription factor binding cysteine-type endopeptidase activator activity involved in apoptotic process mitogen-activated protein kinase kinase kinase binding non-receptor serine/threonine protein kinase
Process(es)
ossification regulation of transcription, DNA-templated protein phosphorylation inflammatory response response to osmotic stress signal transduction JNK cascade JUN phosphorylation response to heat response to UV regulation of gene expression positive regulation of gene expression phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation positive regulation of cell migration regulation of histone deacetylation positive regulation of microtubule polymerization neuron projection development positive regulation of cyclase activity negative regulation of protein binding regulation of protein localization response to hydrogen peroxide regulation of circadian rhythm negative regulation of apoptotic process positive regulation of DNA replication response to cadmium ion determination of dorsal identity rhythmic process positive regulation of protein metabolic process cellular response to hydrogen peroxide cellular response to lipopolysaccharide cellular response to nitric oxide positive regulation of deacetylase activity type B pancreatic cell apoptotic process neuronal stem cell population maintenance programmed necrotic cell death positive regulation of determination of dorsal identity positive regulation of apoptotic signaling pathway MAPK cascade release of cytochrome c from mitochondria positive regulation of protein phosphorylation protein targeting to mitochondrion activation of cysteine-type endopeptidase activity involved in apoptotic process central nervous system development response to mechanical stimulus response to toxic substance response to organic substance positive regulation of macrophage derived foam cell differentiation positive regulation of cell morphogenesis involved in differentiation response to amine positive regulation of prostaglandin biosynthetic process regulation of protein ubiquitination positive regulation of prostaglandin secretion positive regulation of chemokine production cellular response to UV response to drug positive regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of nitric oxide biosynthetic process positive regulation of transcription, DNA-templated regulation of JNK cascade positive regulation of nitric-oxide synthase biosynthetic process cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to growth factor stimulus
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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