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Invitrogen
MAPKAP1 Polyclonal Antibody
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Product Details
PA5-20362
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
An 18 amino acid peptide from near the center of human MAPKAP1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is human skeletal muscle tissue lysate.
PA5-20362 can be used with blocking peptide PEP-0587.
Target Information
Sin1 was initially identified as the human homolog of S. pombe SIN1. Recent evidence has shown that it identical to Mip1, a protein that interacts with MEKK2, a member of the mitogen-activated protein kinase (MAPK) intracellular signaling network. MAPKAP1 is thought to prevent MEKK2 activation and dimerization by forming a complex with the inactive and non-phosphorylated MEKK2, thereby blocking the JNK1/2, ERK1/2, p38 and ERK5 MAPKs. MAPKAP1 has also been shown to play a role in the TOR signaling process, a pathway that is involved in controlling cell growth and proliferation in response to environmental cues such as nutrients, growth factors and hormones. Experiments showed that MAPKAP1 helped to maintain the TOR/rictor assembly but not the TOR/RAPTOR complex, which allowed specific phosphorylation of Akt, a kinase that is believed to couple the growth factor-PI3K signaling pathway to the nutrient-regulated TOR signaling pathway. Multiple alternatively spliced isoforms of MAPKAP1 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MEKK2-interacting protein 1; MGC2745; Mip1a; Mip1b; Mip1r; MIP1SIN1SIN1b; mitogen activated protein kinase associated protein 1; Mitogen-activated protein kinase 2-associated protein 1; mitogen-activated protein kinase associated protein 1; mitogen-activated protein kinase-associated protein 1; MAPKAP1; mSIN1; ras inhibitor MGC2745; RP11-269P11.1; SAPK-interacting protein 1; SIN1; SIN1a; SIN1b; SIN1g; stress-activated map kinase interacting protein 1; Stress-activated map kinase-interacting protein 1; stress-activated protein kinase-interacting 1; Target of rapamycin complex 2 subunit MAPKAP1; TORC2 subunit MAPKAP1; unnamed protein product
Gene Aliases: AI591529; D230039K05Rik; JC310; MAPKAP1; MIP1; SIN1; SIN1b; SIN1g
UniProt ID: (Human) Q9BPZ7, (Rat) Q6AYF1, (Mouse) Q8BKH7
Entrez Gene ID: (Human) 79109, (Rat) 296648, (Mouse) 227743
protein binding
phosphatidylinositol-4,5-bisphosphate binding
phosphatidylinositol-3,4,5-trisphosphate binding
protein kinase binding
small GTPase binding
phosphatidylinositol-3,4-bisphosphate binding
binding, bridging
phosphatidic acid binding
phosphatidylinositol-3,5-bisphosphate binding
enzyme-substrate adaptor activity
molecular_function
Ras GTPase binding
scaffold/adaptor protein
ubiquitin-dependent protein catabolic process
cytoskeleton organization
insulin receptor signaling pathway
substantia nigra development
positive regulation of cell growth
cellular response to nutrient levels
cellular response to insulin stimulus
TORC2 signaling
negative regulation of apoptotic process
protein kinase B signaling
negative regulation of Ras protein signal transduction
negative regulation of insulin receptor signaling pathway
protein stabilization
positive regulation of protein kinase B signaling
regulation of cellular response to oxidative stress
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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