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Immunogen sequence: MLSNSQGQS PPVPFPAPAP PPQPPTPALP HPPAQPPPPP PQQFPQFHVK SGLQIKKNAI IDDYKVTSQV LGLGINGKVL QIFNKRTQEK FALKMLQDCP KARREVELHW RASQCPHIVR IVDVYENLYA GRKCLLIVME CLDGGELFSR IQDRGDQAFT EREASEIMKS IGEAIQYLHS INIAHRDVKP ENLLYTSKRP NAILKLTDFG FAKETTSHNS LTTPCYTPYY VAPEVLGPEK YDKSCDMWSL GVIMYILLCG YPPFYSNHGL AISPGMKTRI RMGQYEFPNP EWSEVSEEVK MLIRNLLKTE PTQRMTITEF MNHPWIMQST KVPQTPLHTS RVLKEDKERW EDVKEEMTSA LATMRVDYEQ IKIKKIEDAS NPLLLKRRKK ARALEAAALA H (1-400 aa encoded by BC036060)
MAPKAPK2 mediates p38 and ERK signaling in vivo. It is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation, and cell proliferation. MAPKAPK2 encodes a member of the Ser/Thr protein kinase family. MAPKAPK2 is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, MAPKAPK2 is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for MAPKAPK2.
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Protein Aliases: MAP kinase-activated protein kinase 2; MAPK-activated protein kinase 2; MAPKAP kinase 2; MAPKAPK-2
Gene Aliases: AA960234; MAPKAP-K2; MAPKAPK2; MK-2; MK2; Rps6kc1
Molecular Function: non-receptor serine/threonine protein kinase