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Invitrogen
MAPKAPK2 Polyclonal Antibody
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FIGURE: 1 / 1
MAPKAPK2 Antibody (PA5-109937) in WB
Western blot analysis of MAPKAPK2 in extracts of rat skeletal muscle. Samples were incubated with MAPKAPK2 Polyclonal antibody (Product # PA5-109937) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 120s.
Product Details
PA5-109937
Product Specifications
Species Reactivity
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 300-400 of human MAPKAPK-2/MK2 (NP_1165842)
Conjugate
Form
Liquid
Concentration
1.88 mg/mL
Amount
188 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MLIRNLLKTE PTQRMTITEF MNHPWIMQST KVPQTPLHTS RVLKEDKERW EDVKEEMTSA LATMRVDYEQ IKIKKIEDAS NPLLLKRRKK ARALEAAALA H
Target Information
MAPKAPK2 mediates p38 and ERK signaling in vivo. It is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation, and cell proliferation. MAPKAPK2 encodes a member of the Ser/Thr protein kinase family. MAPKAPK2 is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, MAPKAPK2 is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for MAPKAPK2.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MAP kinase-activated protein kinase 2
Entrez Gene ID: (Rat) 289014
toll-like receptor signaling pathway
protein phosphorylation
inflammatory response
cellular response to DNA damage stimulus
peptidyl-serine phosphorylation
response to lipopolysaccharide
regulation of interleukin-6 production
regulation of tumor necrosis factor production
response to cytokine
cellular response to vascular endothelial growth factor stimulus
macropinocytosis
vascular endothelial growth factor receptor signaling pathway
mRNA stabilization
inner ear development
3'-UTR-mediated mRNA stabilization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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